Advances in modeling cardiac defibrillation

Felipe Aguel; James Eason; Natalia Trayanova

doi:10.1142/S0218127403008892

Advances in modeling cardiac defibrillation

Felipe Aguel
, James Eason
, Natalia Trayanova

Research output: Contribution to journal › Article › peer-review

Abstract

This paper presents the development of a bidomain model of electrical defibrillation and postshock arrhythmogenesis of the rabbit heart. The model incorporates a realistic representation of cardiac geometry, fiber structure, and membrane ionic processes. Fibrillation is induced in the rabbit heart with burst pacing. Defibrillation shocks of various strengths are delivered to the model in an attempt to terminate the arrhythmia. Two sets of defibrillation simulations are conducted based on the waveform of the defibrillation shock: monophasic and biphasic. The simulations presented here demonstrate the feasibility of modeling realistically the effect of the defibrillation shock on the heart.

Original language	English (US)
Pages (from-to)	3791-3803
Number of pages	13
Journal	International Journal of Bifurcation and Chaos in Applied Sciences and Engineering
Volume	13
Issue number	12
DOIs	https://doi.org/10.1142/S0218127403008892
State	Published - Dec 2003
Externally published	Yes

Keywords

Bidomain model
Biphasic shocks
Defibrillation
Fiber orientation
Finite elements
Monophasic
Spiral wave

ASJC Scopus subject areas

Modeling and Simulation
Engineering (miscellaneous)
General
Applied Mathematics

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10.1142/S0218127403008892

Cite this

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title = "Advances in modeling cardiac defibrillation",

abstract = "This paper presents the development of a bidomain model of electrical defibrillation and postshock arrhythmogenesis of the rabbit heart. The model incorporates a realistic representation of cardiac geometry, fiber structure, and membrane ionic processes. Fibrillation is induced in the rabbit heart with burst pacing. Defibrillation shocks of various strengths are delivered to the model in an attempt to terminate the arrhythmia. Two sets of defibrillation simulations are conducted based on the waveform of the defibrillation shock: monophasic and biphasic. The simulations presented here demonstrate the feasibility of modeling realistically the effect of the defibrillation shock on the heart.",

keywords = "Bidomain model, Biphasic shocks, Defibrillation, Fiber orientation, Finite elements, Monophasic, Spiral wave",

author = "Felipe Aguel and James Eason and Natalia Trayanova",

note = "Funding Information: This research was supported by NIH grants HL63195 and HL67322 (N. Trayanova), NSF grant BES-9809132 (N. Trayanova), and a grant from the Whitaker Foundation (J. Eason). The authors also thank Craig Campbell for generating some of the grids.",

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doi = "10.1142/S0218127403008892",

language = "English (US)",

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AU - Aguel, Felipe

AU - Eason, James

AU - Trayanova, Natalia

N1 - Funding Information: This research was supported by NIH grants HL63195 and HL67322 (N. Trayanova), NSF grant BES-9809132 (N. Trayanova), and a grant from the Whitaker Foundation (J. Eason). The authors also thank Craig Campbell for generating some of the grids.

PY - 2003/12

Y1 - 2003/12

N2 - This paper presents the development of a bidomain model of electrical defibrillation and postshock arrhythmogenesis of the rabbit heart. The model incorporates a realistic representation of cardiac geometry, fiber structure, and membrane ionic processes. Fibrillation is induced in the rabbit heart with burst pacing. Defibrillation shocks of various strengths are delivered to the model in an attempt to terminate the arrhythmia. Two sets of defibrillation simulations are conducted based on the waveform of the defibrillation shock: monophasic and biphasic. The simulations presented here demonstrate the feasibility of modeling realistically the effect of the defibrillation shock on the heart.

AB - This paper presents the development of a bidomain model of electrical defibrillation and postshock arrhythmogenesis of the rabbit heart. The model incorporates a realistic representation of cardiac geometry, fiber structure, and membrane ionic processes. Fibrillation is induced in the rabbit heart with burst pacing. Defibrillation shocks of various strengths are delivered to the model in an attempt to terminate the arrhythmia. Two sets of defibrillation simulations are conducted based on the waveform of the defibrillation shock: monophasic and biphasic. The simulations presented here demonstrate the feasibility of modeling realistically the effect of the defibrillation shock on the heart.

KW - Bidomain model

KW - Biphasic shocks

KW - Defibrillation

KW - Fiber orientation

KW - Finite elements

KW - Monophasic

KW - Spiral wave

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JO - International Journal of Bifurcation and Chaos in Applied Sciences and Engineering

JF - International Journal of Bifurcation and Chaos in Applied Sciences and Engineering

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Advances in modeling cardiac defibrillation

Abstract

Keywords

ASJC Scopus subject areas

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