Abstract
2011 was marked by rapid progress in the identification of basic mechanisms of allergic disease and the translation of these mechanisms into human cell systems. Studies published in the Journal of Allergy and Clinical Immunology this year provided new insights into the molecular determinants of allergenicity, as well as the environmental, cellular, and genetic factors involved in sensitization to allergens. Several articles focused on mechanisms of allergen immunotherapy and the development of novel strategies to achieve tolerance to allergens. Additional studies identified substantial contributions from T H 17-type cells and cytokines to human disease pathogenesis. Finally, new therapeutic applications of anti-IgE were identified. The highlights of these studies and their potential clinical implications are summarized in this review.
Original language | English (US) |
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Pages (from-to) | 335-341 |
Number of pages | 7 |
Journal | Journal of Allergy and Clinical Immunology |
Volume | 129 |
Issue number | 2 |
DOIs | |
State | Published - Feb 2012 |
Keywords
- Galactose-α-1,3-galactose
- Toll-like receptor
- calcitonin gene-related peptide
- cyclic AMP
- dendritic cell
- facilitated antigen binding
- facilitated antigen presentation
- genome-wide association study
- interferon
- lipopolysaccharide
- toluidine diisothiocyanate
- vascular endothelial growth factor
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology