Advances and future applications of augmented peripheral nerve regeneration

Salazar Jones, Howard M. Eisenberg, Xiaofeng Jia

Research output: Contribution to journalReview articlepeer-review

43 Scopus citations


Peripheral nerve injuries remain a significant source of long lasting morbidity, disability, and economic costs. Much research continues to be performed in areas related to improving the surgical outcomes of peripheral nerve repair. In this review, the physiology of peripheral nerve regeneration and the multitude of efforts to improve surgical outcomes are discussed. Improvements in tissue engineering that have allowed for the use of synthetic conduits seeded with neurotrophic factors are highlighted. Selected pre-clinical and available clinical data using cell based methods such as Schwann cell, undifferentiated, and differentiated stem cell transplantation to guide and enhance peripheral nerve regeneration are presented. The limitations that still exist in the utility of neurotrophic factors and cell-based therapies are outlined. Strategies that are most promising for translation into the clinical arena are suggested.

Original languageEnglish (US)
Article number1494
JournalInternational journal of molecular sciences
Issue number9
StatePublished - Sep 7 2016


  • Nerve conduits
  • Neurotrophic factors
  • Peripheral nerve
  • Peripheral nerve regeneration
  • Stem cells

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry


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