Advanced magnetic resonance spectroscopic neuroimaging: Experts' consensus recommendations

Andrew A. Maudsley, Ovidiu C. Andronesi, Peter B. Barker, Alberto Bizzi, Wolfgang Bogner, Anke Henning, Sarah J. Nelson, Stefan Posse, Dikoma C. Shungu, Brian J. Soher

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations


Magnetic resonance spectroscopic imaging (MRSI) offers considerable promise for monitoring metabolic alterations associated with disease or injury; however, to date, these methods have not had a significant impact on clinical care, and their use remains largely confined to the research community and a limited number of clinical sites. The MRSI methods currently implemented on clinical MRI instruments have remained essentially unchanged for two decades, with only incremental improvements in sequence implementation. During this time, a number of technological developments have taken place that have already greatly benefited the quality of MRSI measurements within the research community and which promise to bring advanced MRSI studies to the point where the technique becomes a true imaging modality, while making the traditional review of individual spectra a secondary requirement. Furthermore, the increasing use of biomedical MR spectroscopy studies has indicated clinical areas where advanced MRSI methods can provide valuable information for clinical care. In light of this rapidly changing technological environment and growing understanding of the value of MRSI studies for biomedical studies, this article presents a consensus from a group of experts in the field that reviews the state-of-the-art for clinical proton MRSI studies of the human brain, recommends minimal standards for further development of vendor-provided MRSI implementations, and identifies areas which need further technical development.

Original languageEnglish (US)
Article numbere4309
JournalNMR in biomedicine
Issue number5
StatePublished - May 2021


  • brain
  • magnetic resonance spectroscopic imaging
  • review

ASJC Scopus subject areas

  • Molecular Medicine
  • Radiology Nuclear Medicine and imaging
  • Spectroscopy


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