TY - JOUR
T1 - Adult Neurogenesis in the Mammalian Brain
T2 - Significant Answers and Significant Questions
AU - Ming, Guo li
AU - Song, Hongjun
PY - 2011/5/26
Y1 - 2011/5/26
N2 - Adult neurogenesis, a process of generating functional neurons from adult neural precursors, occurs throughout life in restricted brain regions in mammals. The past decade has witnessed tremendous progress in addressing questions related to almost every aspect of adult neurogenesis in the mammalian brain. Here we review major advances in our understanding of adult mammalian neurogenesis in the dentate gyrus of the hippocampus and from the subventricular zone of the lateral ventricle, the rostral migratory stream to the olfactory bulb. We highlight emerging principles that have significant implications for stem cell biology, developmental neurobiology, neural plasticity, and disease mechanisms. We also discuss remaining questions related to adult neural stem cells and their niches, underlying regulatory mechanisms, and potential functions of newborn neurons in the adult brain. Building upon the recent progress and aided by new technologies, the adult neurogenesis field is poised to leap forward in the next decade.
AB - Adult neurogenesis, a process of generating functional neurons from adult neural precursors, occurs throughout life in restricted brain regions in mammals. The past decade has witnessed tremendous progress in addressing questions related to almost every aspect of adult neurogenesis in the mammalian brain. Here we review major advances in our understanding of adult mammalian neurogenesis in the dentate gyrus of the hippocampus and from the subventricular zone of the lateral ventricle, the rostral migratory stream to the olfactory bulb. We highlight emerging principles that have significant implications for stem cell biology, developmental neurobiology, neural plasticity, and disease mechanisms. We also discuss remaining questions related to adult neural stem cells and their niches, underlying regulatory mechanisms, and potential functions of newborn neurons in the adult brain. Building upon the recent progress and aided by new technologies, the adult neurogenesis field is poised to leap forward in the next decade.
UR - http://www.scopus.com/inward/record.url?scp=79956209852&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79956209852&partnerID=8YFLogxK
U2 - 10.1016/j.neuron.2011.05.001
DO - 10.1016/j.neuron.2011.05.001
M3 - Article
C2 - 21609825
AN - SCOPUS:79956209852
SN - 0896-6273
VL - 70
SP - 687
EP - 702
JO - Neuron
JF - Neuron
IS - 4
ER -