@article{acd400cd8e5a494599c2fccd05c49b6e,
title = "Adult Height, Prevalent Coronary Artery Calcium Score, and Incident Cardiovascular Disease Outcomes in a Multiethnic Cohort",
abstract = "We assessed the relationships among adult height, coronary artery calcium (CAC) score, incident atherosclerotic cardiovascular disease (ASCVD) events, and atrial fibrillation (AFib) in a multiethnic cohort. We used race/ethnicityspecific height (dichotomized by median value and in quartiles) as the predictor variable within the 4 racial/ethnic groups in the Multi-Ethnic Study of Atherosclerosis (n = 6,814). After a mean of 10.2 years of follow-up (2000-2012), 556 ASCVD events (8.2%) and 539 AFib events (7.9%) occurred. Adult height was not associated with prevalent CAC score (ln(CAC + 1) or categories). Tall stature (i.e., race/ethnicity-specific height ≥median) had a significant but opposite association with future ASCVD and AFib (hazard ratios were 0.72 (95% confidence interval: 0.56, 0.92) and 1.38 (95% confidence interval: 1.07, 1.79), respectively). We observed a gradient-response but opposite association between quartiles of race/ethnicity-specific height and ASCVD/AFib events in our multivariable models. A formal test of interaction between race/ethnicity-specific height and sex was not significant in the ASCVD model (P = 0.78) but was significant in the AFibmodel (P = 0.03). Tall stature was associated (in a gradient-response fashion) with reduced risk of ASCVD events and increased risk of AFib. Adult height may signal interactions between genetic and environmental factors and may provide risk information independent of current traditional risk factors and CAC score.",
keywords = "Adult height, Atherosclerotic cardiovascular disease, Atrial fibrillation, Cardiovascular disease, Coronary artery calcium score",
author = "Joseph Yeboah and Blaha, {Michael J.} and Michos, {Erin D.} and Waqas Qureshi and Michael Miedema and Peter Flueckiger and Rodriguez, {Carlos J.} and Moyses Szklo and Bertoni, {Alain G.}",
note = "Funding Information: We assessed associations among adult height, prevalent coronary artery calcium (CAC) score, 10 years of adjudicated incident atherosclerotic cardiovascular disease (ASCVD), and atrial fibrillation in the Multi-Ethnic Study of Atherosclerosis (MESA), an ongoing prospective study funded by the National Heart, Lung, and Blood Institute. Funding Information: Author affiliations: Heart and Vascular Center of Excellence, School of Medicine, Wake Forest University, Winston-Salem, North Carolina (Joseph Yeboah, Waqas Qureshi, Peter Flueckiger, Carlos J. Rodriguez); Ciccarone Center for the Prevention of Heart Disease, School of Medicine, Johns Hopkins University, Baltimore, Maryland (Michael J. Blaha, Erin D. Michos); Department of Epidemiology, School of Medicine, Wake Forest University, Winston-Salem, North Carolina (Carlos J. Rodriguez, Alain G. Bertoni); Minneapolis Heart Institute and Minneapolis Heart Institute Foundation, Minneapolis, Minnesota (Michael Miedema); and Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland (Moyses Szklo). This research was supported by contracts HHSN268201500003I, N01-HC-95159, N01-HC-95160, N01-HC-95161, N01-HC-95162, N01-HC-95163, N01-HC-95164, N01-HC-95165, N01-HC-95166, N01-HC-95167, N01-HC-95168, and N01-HC-95169 from the National Heart, Lung, and Blood Institute and by grants UL1-TR-000040 and UL1-TR-001079 from the National Center for Research Resources. We thank the investigators and staff of the MESA study for their valuable contributions. We also acknowledge the editorial assistance of Karen Klein of the Wake Forest Clinical and Translational Science Institute. A full list of participating MESA investigators and institutions can be found at http://www.mesa-nhlbi.org. Conflict of interest: none declared. Publisher Copyright: {\textcopyright} 2017 The Author(s). Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. All rights reserved.",
year = "2017",
month = oct,
day = "15",
doi = "10.1093/aje/kwx165",
language = "English (US)",
volume = "186",
pages = "935--943",
journal = "American journal of epidemiology",
issn = "0002-9262",
publisher = "Oxford University Press",
number = "8",
}