TY - JOUR
T1 - Adult-Attained Height and Colorectal Cancer Risk
T2 - A Cohort Study, Systematic Review, and Meta-Analysis
AU - Zhou, Elinor
AU - Wang, Lin
AU - Santiago, Celina N.
AU - Nanavati, Julie
AU - Rifkin, Samara
AU - Spence, Emma
AU - Hylind, Linda M.
AU - Gills, Joell J.
AU - Luna, Louis La
AU - Kafonek, David R.
AU - Cromwell, David M.
AU - Drewes, Julia L.
AU - Sears, Cynthia L.
AU - Giardiello, Francis M.
AU - Mullin, Gerard E.
N1 - Funding Information:
This study was supported by grants R01CA196845 (to C.L. Sears, F. Giardello, C.N.Santiago, J. Drewes, G. Mullin, E. Spence, D. Kafonek, D.M. Cromwell, L. LaLuna), Bloomberg Philanthropies (to C.L. Santiago, J.J. Gills), T32DK007632 (to S. Rifkin), intramural funds (to L.M. Hylind), and the Johns Hopkins Cancer Center Support Grant, NCI P30CA006973 (to C.L. Santiago, F.M. Giardello). All data from R01CA196845 (Johns Hopkins University) were stored in Research Electronic Data Capture (REDCap). The content of this article is solely the responsibility of the authors and does not necessarily represent the official views of the NCI or the NIH. The authors thank all members of the Sears laboratory for assistance with the Biofilm Colonoscopy Study. Biofilm Study Consortium authors: Madison McMann (Johns Hopkins University School of Medicine), Courtney Stevens (Johns Hopkins University School of Medicine), Brent Tabisz (Johns Hopkins University School of Medicine), Marshall Bedine (Green Spring Station Endoscopy), Eduardo Gonzalez-Velez (Johns Hopkins University School of Medicine), Hazel Marie Galon Veloso (Johns Hopkins University School of Medicine), Pamela Schearer (Reading Hospital, Tower Health), Stacy Gerhart (Digestive Diseases Associates), Amy Schiller (Digestive Disease Associates), Karin Donato (Digestive Disease Associates), Randi Sweigart (Digestive Disease Associates), John Altomare (Digestive Disease Associates), Nirav Shah (Digestive Disease Associates), Christopher Ibrahim (Digestive Disease Associates), Ravi Ghanta (Digestive Disease Associates).
Publisher Copyright:
© 2022 American Association for Cancer Research.
PY - 2022/4
Y1 - 2022/4
N2 - Background: The influence of anthropometric characteristics on colorectal neoplasia biology is unclear. We conducted a systematic review and meta-analysis to determine if adult-attained height is independently associated with the risk of colorectal cancer or adenoma. Methods: We searched MEDLINE, EMBASE, the Cochrane Library, and Web of Science from inception to August 2020 for studies on the association between adult-attained height and colorectal cancer or adenoma. The original data from the Johns Hopkins (Baltimore, MD) Colon Biofilm study was also included. The overall HR/OR of colorectal cancer/adenoma with increased height was estimated using random-effects meta-analysis. Results: We included 47 observational studies involving 280,644 colorectal cancer and 14,139 colorectal adenoma cases. Thirty-three studies reported data for colorectal cancer incidence per 10-cm increase in height; 19 yielded anHRof 1.14 [95% confidence interval (CI), 1.11-1.17; P < 0.001), and 14 engendered an OR of 1.09 (95% CI, 1.05-1.13; P < 0.001). Twenty-six studies compared colorectal cancer incidence between individuals within the highest versus the lowest height percentile; 19 indicated an HR of 1.24 (95% CI, 1.19- 1.30; P < 0.001), and seven resulting in an OR of 1.07 (95% CI, 0.92- 1.25; P = 0.39). Four studies reported data for assessing colorectal adenoma incidence per 10-cm increase in height, showing an overall OR of 1.06 (95% CI, 1.00-1.12; P = 0.03). Conclusions: Greater adult attained height is associated with an increased risk of colorectal cancer and adenoma.
AB - Background: The influence of anthropometric characteristics on colorectal neoplasia biology is unclear. We conducted a systematic review and meta-analysis to determine if adult-attained height is independently associated with the risk of colorectal cancer or adenoma. Methods: We searched MEDLINE, EMBASE, the Cochrane Library, and Web of Science from inception to August 2020 for studies on the association between adult-attained height and colorectal cancer or adenoma. The original data from the Johns Hopkins (Baltimore, MD) Colon Biofilm study was also included. The overall HR/OR of colorectal cancer/adenoma with increased height was estimated using random-effects meta-analysis. Results: We included 47 observational studies involving 280,644 colorectal cancer and 14,139 colorectal adenoma cases. Thirty-three studies reported data for colorectal cancer incidence per 10-cm increase in height; 19 yielded anHRof 1.14 [95% confidence interval (CI), 1.11-1.17; P < 0.001), and 14 engendered an OR of 1.09 (95% CI, 1.05-1.13; P < 0.001). Twenty-six studies compared colorectal cancer incidence between individuals within the highest versus the lowest height percentile; 19 indicated an HR of 1.24 (95% CI, 1.19- 1.30; P < 0.001), and seven resulting in an OR of 1.07 (95% CI, 0.92- 1.25; P = 0.39). Four studies reported data for assessing colorectal adenoma incidence per 10-cm increase in height, showing an overall OR of 1.06 (95% CI, 1.00-1.12; P = 0.03). Conclusions: Greater adult attained height is associated with an increased risk of colorectal cancer and adenoma.
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U2 - 10.1158/1055-9965.EPI-21-0398
DO - 10.1158/1055-9965.EPI-21-0398
M3 - Article
C2 - 35247904
AN - SCOPUS:85128161186
SN - 1055-9965
VL - 31
SP - 783
EP - 792
JO - Cancer Epidemiology Biomarkers and Prevention
JF - Cancer Epidemiology Biomarkers and Prevention
IS - 4
ER -