Abstract
We studied the pressor response to norepinephrine infusion in patients with an autosomal dominant adult-onset leukodystrophy. We also examined cardiovascular and catecholamine responses to insulin-induced hypoglycemia. A parallel shift to the left of the norepinephrine dose response curve, in conjunction with low baseline plasma norepinephrine levels, was consistent with denervation supersensitivity, suggesting a distal lesion of sympathetic nor-adrenergic neurons. Absence of the epinephrine response to insulin-induced hypoglycemia indicated that autonomic neuropathy was attended by severe adrenal medullary dysfunction.
Original language | English (US) |
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Pages (from-to) | 1421-1424 |
Number of pages | 4 |
Journal | Neurology |
Volume | 37 |
Issue number | 8 |
State | Published - 1987 |
Externally published | Yes |
ASJC Scopus subject areas
- Arts and Humanities (miscellaneous)
- Clinical Neurology
- General Neuroscience