Adrenal function during the use of dexamethasone aerosols in the treatment of ragweed hay fever

Philip S. Norman; Walter L. Winkenwerder; Benigno F. Agbayani; Claude J. Migeon

doi:10.1016/0021-8707(67)90060-3

Adrenal function during the use of dexamethasone aerosols in the treatment of ragweed hay fever

Philip S. Norman, Walter L. Winkenwerder, Benigno F. Agbayani, Claude J. Migeon

Research output: Contribution to journal › Article › peer-review

53 Scopus citations

Abstract

The use of Freon propelled dexamethasone nasal spray (Turbinaire) in nasal allergy successfully alleviates symptoms but may cause partial suppression of adrenal function. To evaluate the significance of adrenal suppression in hay fever, the 17-hydroxy-steroid excretion of seven patients was followed through a ragweed hay fever season. Partial adrenal suppression was observed in four of the patients and temporary complete suppression was observed in one. After discontinuance of the drug a prompt return of normal adrenal secretion was observed. The risk of long-term adrenal suppression from the seasonal use of Turbinaire seems small.

Original language	English (US)
Pages (from-to)	57-61
Number of pages	5
Journal	Journal of Allergy
Volume	40
Issue number	1
DOIs	https://doi.org/10.1016/0021-8707(67)90060-3
State	Published - Jul 1967
Externally published	Yes

ASJC Scopus subject areas

General Medicine

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title = "Adrenal function during the use of dexamethasone aerosols in the treatment of ragweed hay fever",

abstract = "The use of Freon propelled dexamethasone nasal spray (Turbinaire) in nasal allergy successfully alleviates symptoms but may cause partial suppression of adrenal function. To evaluate the significance of adrenal suppression in hay fever, the 17-hydroxy-steroid excretion of seven patients was followed through a ragweed hay fever season. Partial adrenal suppression was observed in four of the patients and temporary complete suppression was observed in one. After discontinuance of the drug a prompt return of normal adrenal secretion was observed. The risk of long-term adrenal suppression from the seasonal use of Turbinaire seems small.",

author = "Norman, {Philip S.} and Winkenwerder, {Walter L.} and Agbayani, {Benigno F.} and Migeon, {Claude J.}",

note = "Funding Information: From the Division of Allergy and Infectious Harriet Lane Service of the Children{\textquoteright}s Medical versity and Hospital. Supported by a grant from the Merck Sharpe Health Service Research Grant AM-00180, Research Research Career Award AM-21855. Received for publication March 23, 1967. *Fellow of the China Medical Board of New Philippines, Manila, Philippines.",

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AU - Norman, Philip S.

AU - Winkenwerder, Walter L.

AU - Agbayani, Benigno F.

AU - Migeon, Claude J.

N1 - Funding Information: From the Division of Allergy and Infectious Harriet Lane Service of the Children’s Medical versity and Hospital. Supported by a grant from the Merck Sharpe Health Service Research Grant AM-00180, Research Research Career Award AM-21855. Received for publication March 23, 1967. *Fellow of the China Medical Board of New Philippines, Manila, Philippines.

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N2 - The use of Freon propelled dexamethasone nasal spray (Turbinaire) in nasal allergy successfully alleviates symptoms but may cause partial suppression of adrenal function. To evaluate the significance of adrenal suppression in hay fever, the 17-hydroxy-steroid excretion of seven patients was followed through a ragweed hay fever season. Partial adrenal suppression was observed in four of the patients and temporary complete suppression was observed in one. After discontinuance of the drug a prompt return of normal adrenal secretion was observed. The risk of long-term adrenal suppression from the seasonal use of Turbinaire seems small.

AB - The use of Freon propelled dexamethasone nasal spray (Turbinaire) in nasal allergy successfully alleviates symptoms but may cause partial suppression of adrenal function. To evaluate the significance of adrenal suppression in hay fever, the 17-hydroxy-steroid excretion of seven patients was followed through a ragweed hay fever season. Partial adrenal suppression was observed in four of the patients and temporary complete suppression was observed in one. After discontinuance of the drug a prompt return of normal adrenal secretion was observed. The risk of long-term adrenal suppression from the seasonal use of Turbinaire seems small.

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Adrenal function during the use of dexamethasone aerosols in the treatment of ragweed hay fever

Abstract

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