TY - JOUR
T1 - Adipose tissue density, a novel biomarker predicting mortality risk in older adults
AU - Murphy, Rachel A.
AU - Register, Thomas C.
AU - Shively, Carol A.
AU - Carr, J. Jeffrey
AU - Ge, Yaorong
AU - Heilbrun, Marta E.
AU - Cummings, Steven R.
AU - Koster, Annemarie
AU - Nevitt, Michael C.
AU - Satterfield, Suzanne
AU - Tylvasky, Frances A.
AU - Strotmeyer, Elsa S.
AU - Newman, Anne B.
AU - Simonsick, Eleanor M.
AU - Scherzinger, Ann
AU - Goodpaster, Bret H.
AU - Launer, Lenore J.
AU - Eiriksdottir, Gudny
AU - Sigurdsson, Sigurdur
AU - Sigurdsson, Gunnar
AU - Gudnason, Vilmundur
AU - Lang, Thomas F.
AU - Kritchevsky, Stephen B.
AU - Harris, Tamara B.
N1 - Funding Information:
Supplementary Material Supplementary material can be found at: http://biomedgerontology. oxfordjournals.org Funding This work was supported by National Institutes of Health (N01-AG-6-2101, N01-AG-6-2103, N01-AG-6-2106; R01-AG28050, R01-AG28641, R01-HL39789, R01-NR-12459) and the Pepper Older Americans for Independence Center (P30 AG21332). This research was supported in part by the Intramural Research Program of the National Institutes of Health, National Institute on Aging. R.A.M. is supported by a Banting Postdoctoral Fellowship.
PY - 2014/1
Y1 - 2014/1
N2 - Background. Knowledge of adipose composition in relation to mortality may help delineate inconsistent relationships between obesity and mortality in old age. We evaluated relationships between abdominal visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) density, mortality, biomarkers, and characteristics. Methods. VAT and SAT density were determined from computed tomography scans in persons aged 65 and older, Health ABC (n = 2,735) and AGES-Reykjavik (n = 5,131), and 24 nonhuman primates (NHPs). Associations between adipose density and mortality (4-13 years follow-up) were assessed with Cox proportional hazards models. In NHPs, adipose density was related to serum markers and tissue characteristics. Results .Higher density adipose tissue was associated with mortality in both studies with adjustment for risk factors including adipose area, total fat, and body mass index. In women, hazard ratio and 95% CI for the densest quintile (Q5) versus least dense (Q1) for VAT density were 1.95 (1.36-2.80; Health ABC) and 1.88 (1.31-2.69; AGES-Reykjavik) and for SAT density, 1.76 (1.35-2.28; Health ABC) and 1.56 (1.15-2.11; AGES-Reykjavik). In men, VAT density was associated with mortality in Health ABC, 1.52 (1.12-2.08), whereas SAT density was associated with mortality in both Health ABC, 1.58 (1.21-2.07), and AGES-Reykjavik, 1.43 (1.07-1.91). Higher density adipose tissue was associated with smaller adipocytes in NHPs. There were no consistent associations with inflammation in any group. Higher density adipose tissue was associated with lower serum leptin in Health ABC and NHPs, lower leptin mRNA expression in NHPs, and higher serum adiponectin in Health ABC and NHPs. Conclusion. VAT and SAT density provide a unique marker of mortality risk that does not appear to be inflammation related.
AB - Background. Knowledge of adipose composition in relation to mortality may help delineate inconsistent relationships between obesity and mortality in old age. We evaluated relationships between abdominal visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) density, mortality, biomarkers, and characteristics. Methods. VAT and SAT density were determined from computed tomography scans in persons aged 65 and older, Health ABC (n = 2,735) and AGES-Reykjavik (n = 5,131), and 24 nonhuman primates (NHPs). Associations between adipose density and mortality (4-13 years follow-up) were assessed with Cox proportional hazards models. In NHPs, adipose density was related to serum markers and tissue characteristics. Results .Higher density adipose tissue was associated with mortality in both studies with adjustment for risk factors including adipose area, total fat, and body mass index. In women, hazard ratio and 95% CI for the densest quintile (Q5) versus least dense (Q1) for VAT density were 1.95 (1.36-2.80; Health ABC) and 1.88 (1.31-2.69; AGES-Reykjavik) and for SAT density, 1.76 (1.35-2.28; Health ABC) and 1.56 (1.15-2.11; AGES-Reykjavik). In men, VAT density was associated with mortality in Health ABC, 1.52 (1.12-2.08), whereas SAT density was associated with mortality in both Health ABC, 1.58 (1.21-2.07), and AGES-Reykjavik, 1.43 (1.07-1.91). Higher density adipose tissue was associated with smaller adipocytes in NHPs. There were no consistent associations with inflammation in any group. Higher density adipose tissue was associated with lower serum leptin in Health ABC and NHPs, lower leptin mRNA expression in NHPs, and higher serum adiponectin in Health ABC and NHPs. Conclusion. VAT and SAT density provide a unique marker of mortality risk that does not appear to be inflammation related.
KW - Adiponectin
KW - Aging
KW - Leptin
KW - Obesity
UR - https://www.scopus.com/pages/publications/84886417898
UR - https://www.scopus.com/pages/publications/84886417898#tab=citedBy
U2 - 10.1093/gerona/glt070
DO - 10.1093/gerona/glt070
M3 - Article
C2 - 23707956
AN - SCOPUS:84886417898
SN - 1079-5006
VL - 69
SP - 109
EP - 117
JO - Journals of Gerontology - Series A Biological Sciences and Medical Sciences
JF - Journals of Gerontology - Series A Biological Sciences and Medical Sciences
IS - 1
ER -