Adiponectin level and left ventricular hypertrophy in Japanese men

Hirotsugu Mitsuhashi, Hiroshi Yatsuya, Koji Tamakoshi, Kunihiro Matsushita, Rei Otsuka, Keiko Wada, Kaichiro Sugiura, Seiko Takefuji, Yo Hotta, Takahisa Kondo, Toyoaki Murohara, Hideaki Toyoshima

Research output: Contribution to journalArticlepeer-review

50 Scopus citations


A recent study has demonstrated that adiponectin inhibited hypertrophic signaling in the myocardium of mice, implying that a decrease in the blood adiponectin level could cause cardiac muscle hypertrophy. We hypothesized that a relationship might exist between the serum adiponectin level and electrocardiographically diagnosed left ventricular hypertrophy (ECG-LVH), and we examined this hypothesis by epidemiological study of 2839 Japanese male workers who were not taking medications for hypertension. ECG-LVH was defined as meeting Sokolow-Lyon voltage criteria and/or Cornell voltage-duration product. The subjects were categorized by tertiles of serum adiponectin level, and a multivariate logistic regression analysis was conducted relating left ventricular hypertrophy to adiponectin tertiles adjusting for potential confounding factors. Prevalence of ECG-LVH in the studied sample was 16.7%. Adiponectin ranged from 1.0 to 5.0 μg/mL in the lowest category and from 7.4 to 30.6 μg/mL in the highest. Compared with subjects in the highest adiponectin category, those in the lowest one had a significantly higher prevalence of ECG-LVH independent of age, body mass index, and systolic blood pressure with an odds ratio of 1.50 and a 95% CI of 1.16 to 1.94. Further adjustment for high-density lipoprotein cholesterol, triglyceride, and insulin resistance did not change the association (odds ratio: 1.68; 95% CI: 1.28 to 2.21; P<0.001). Similar results were obtained when different criteria for ECG-LVH were used or when subjects were stratified by blood pressure or body mass index. Adiponectin concentration was inversely and independently associated with ECG-LVH in Japanese men.

Original languageEnglish (US)
Pages (from-to)1448-1454
Number of pages7
Issue number6
StatePublished - Jun 2007
Externally publishedYes


  • Adiponectin
  • Electrocardiography
  • Epidemiologic study
  • Japanese
  • Left ventricular hypertrophy

ASJC Scopus subject areas

  • Internal Medicine


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