Adiponectin concentrations: A genome-wide association study

Sun Ha Jee; Jae Woong Sull; Jong Eun Lee; Chol Shin; Jongkeun Park; Heejin Kimm; Eun Young Cho; Eun Soon Shin; Ji Eun Yun; Ji Wan Park; Sang Yeun Kim; Sun Ju Lee; Eun Jung Jee; Inkyung Baik; Linda Kao; Sungjoo Kim Yoon; Yangsoo Jang; Terri H. Beaty

doi:10.1016/j.ajhg.2010.09.004

Adiponectin concentrations: A genome-wide association study

Sun Ha Jee, Jae Woong Sull, Jong Eun Lee, Chol Shin, Jongkeun Park, Heejin Kimm, Eun Young Cho, Eun Soon Shin, Ji Eun Yun, Ji Wan Park, Sang Yeun Kim, Sun Ju Lee, Eun Jung Jee, Inkyung Baik, Linda Kao, Sungjoo Kim Yoon, Yangsoo Jang, Terri H. Beaty

School of Medicine

Research output: Contribution to journal › Article › peer-review

119 Scopus citations

Abstract

Adiponectin is associated with obesity and insulin resistance. To date, there has been no genome-wide association study (GWAS) of adiponectin levels in Asians. Here we present a GWAS of a cohort of Korean volunteers. A total of 4,001 subjects were genotyped by using a genome-wide marker panel in a two-stage design (979 subjects initially and 3,022 in a second stage). Another 2,304 subjects were used for follow-up replication studies with selected markers. In the discovery phase, the top SNP associated with mean log adiponectin was rs3865188 in CDH13 on chromosome 16 (p = 1.69 × 10^-15 in the initial sample, p = 6.58 × 10^-39 in the second genome-wide sample, and p = 2.12 × 10^-32 in the replication sample). The meta-analysis p value for rs3865188 in all 6,305 individuals was 2.82 × 10^-83. The association of rs3865188 with high-molecular-weight adiponectin (p = 7.36 × 10^-58) was even stronger in the third sample. A reporter assay that evaluated the effects of a CDH13 promoter SNP in complete linkage disequilibrium with rs3865188 revealed that the major allele increased expression 2.2-fold. This study clearly shows that genetic variants in CDH13 influence adiponectin levels in Korean adults.

Original language	English (US)
Pages (from-to)	545-552
Number of pages	8
Journal	American journal of human genetics
Volume	87
Issue number	4
DOIs	https://doi.org/10.1016/j.ajhg.2010.09.004
State	Published - Oct 8 2010

ASJC Scopus subject areas

Genetics
Genetics(clinical)

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Jee, S. H., Sull, J. W., Lee, J. E., Shin, C., Park, J., Kimm, H., Cho, E. Y., Shin, E. S., Yun, J. E., Park, J. W., Kim, S. Y., Lee, S. J., Jee, E. J., Baik, I., Kao, L., Yoon, S. K., Jang, Y., & Beaty, T. H. (2010). Adiponectin concentrations: A genome-wide association study. American journal of human genetics, 87(4), 545-552. https://doi.org/10.1016/j.ajhg.2010.09.004

@article{1471b09e141f4597a602e5835352fe1a,

title = "Adiponectin concentrations: A genome-wide association study",

abstract = "Adiponectin is associated with obesity and insulin resistance. To date, there has been no genome-wide association study (GWAS) of adiponectin levels in Asians. Here we present a GWAS of a cohort of Korean volunteers. A total of 4,001 subjects were genotyped by using a genome-wide marker panel in a two-stage design (979 subjects initially and 3,022 in a second stage). Another 2,304 subjects were used for follow-up replication studies with selected markers. In the discovery phase, the top SNP associated with mean log adiponectin was rs3865188 in CDH13 on chromosome 16 (p = 1.69 × 10-15 in the initial sample, p = 6.58 × 10-39 in the second genome-wide sample, and p = 2.12 × 10-32 in the replication sample). The meta-analysis p value for rs3865188 in all 6,305 individuals was 2.82 × 10-83. The association of rs3865188 with high-molecular-weight adiponectin (p = 7.36 × 10-58) was even stronger in the third sample. A reporter assay that evaluated the effects of a CDH13 promoter SNP in complete linkage disequilibrium with rs3865188 revealed that the major allele increased expression 2.2-fold. This study clearly shows that genetic variants in CDH13 influence adiponectin levels in Korean adults.",

author = "Jee, {Sun Ha} and Sull, {Jae Woong} and Lee, {Jong Eun} and Chol Shin and Jongkeun Park and Heejin Kimm and Cho, {Eun Young} and Shin, {Eun Soon} and Yun, {Ji Eun} and Park, {Ji Wan} and Kim, {Sang Yeun} and Lee, {Sun Ju} and Jee, {Eun Jung} and Inkyung Baik and Linda Kao and Yoon, {Sungjoo Kim} and Yangsoo Jang and Beaty, {Terri H.}",

note = "Funding Information: This study was funded by the Seoul R&BD Program (10526) and was partially supported by a grant from the Korea Healthcare Technology R&D Project, Ministry for Health, Welfare and Family Affairs, Republic of Korea (A000385). ",

year = "2010",

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doi = "10.1016/j.ajhg.2010.09.004",

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T1 - Adiponectin concentrations

T2 - A genome-wide association study

AU - Jee, Sun Ha

AU - Sull, Jae Woong

AU - Lee, Jong Eun

AU - Shin, Chol

AU - Park, Jongkeun

AU - Kimm, Heejin

AU - Cho, Eun Young

AU - Shin, Eun Soon

AU - Yun, Ji Eun

AU - Park, Ji Wan

AU - Kim, Sang Yeun

AU - Lee, Sun Ju

AU - Jee, Eun Jung

AU - Baik, Inkyung

AU - Kao, Linda

AU - Yoon, Sungjoo Kim

AU - Jang, Yangsoo

AU - Beaty, Terri H.

N1 - Funding Information: This study was funded by the Seoul R&BD Program (10526) and was partially supported by a grant from the Korea Healthcare Technology R&D Project, Ministry for Health, Welfare and Family Affairs, Republic of Korea (A000385).

PY - 2010/10/8

Y1 - 2010/10/8

N2 - Adiponectin is associated with obesity and insulin resistance. To date, there has been no genome-wide association study (GWAS) of adiponectin levels in Asians. Here we present a GWAS of a cohort of Korean volunteers. A total of 4,001 subjects were genotyped by using a genome-wide marker panel in a two-stage design (979 subjects initially and 3,022 in a second stage). Another 2,304 subjects were used for follow-up replication studies with selected markers. In the discovery phase, the top SNP associated with mean log adiponectin was rs3865188 in CDH13 on chromosome 16 (p = 1.69 × 10-15 in the initial sample, p = 6.58 × 10-39 in the second genome-wide sample, and p = 2.12 × 10-32 in the replication sample). The meta-analysis p value for rs3865188 in all 6,305 individuals was 2.82 × 10-83. The association of rs3865188 with high-molecular-weight adiponectin (p = 7.36 × 10-58) was even stronger in the third sample. A reporter assay that evaluated the effects of a CDH13 promoter SNP in complete linkage disequilibrium with rs3865188 revealed that the major allele increased expression 2.2-fold. This study clearly shows that genetic variants in CDH13 influence adiponectin levels in Korean adults.

AB - Adiponectin is associated with obesity and insulin resistance. To date, there has been no genome-wide association study (GWAS) of adiponectin levels in Asians. Here we present a GWAS of a cohort of Korean volunteers. A total of 4,001 subjects were genotyped by using a genome-wide marker panel in a two-stage design (979 subjects initially and 3,022 in a second stage). Another 2,304 subjects were used for follow-up replication studies with selected markers. In the discovery phase, the top SNP associated with mean log adiponectin was rs3865188 in CDH13 on chromosome 16 (p = 1.69 × 10-15 in the initial sample, p = 6.58 × 10-39 in the second genome-wide sample, and p = 2.12 × 10-32 in the replication sample). The meta-analysis p value for rs3865188 in all 6,305 individuals was 2.82 × 10-83. The association of rs3865188 with high-molecular-weight adiponectin (p = 7.36 × 10-58) was even stronger in the third sample. A reporter assay that evaluated the effects of a CDH13 promoter SNP in complete linkage disequilibrium with rs3865188 revealed that the major allele increased expression 2.2-fold. This study clearly shows that genetic variants in CDH13 influence adiponectin levels in Korean adults.

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SP - 545

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JO - American journal of human genetics

JF - American journal of human genetics

IS - 4

ER -

Adiponectin concentrations: A genome-wide association study

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