Adiponectin concentration in the orbital fat of patients with Ggraves' ophthalmopathy

Uri Soiberman, Ran Levy, Igal Leibovitch

Research output: Contribution to journalArticlepeer-review


Background: "Graves' ophthalmopathy" (GO), is an inflammatory disease of the orbit, with extensive adipose tissue involvement. Previous studies of orbital fat derived from such patients have demonstrated overexpression of the adiponectin gene and messenger RNA. Aim: The study reported here aimed to measure the protein concentration of orbital adipose tissue adiponectin in GO patients, in comparison to healthy controls. Methods: This was a prospective study. Orbital samples from ten healthy controls undergoing blepharoplasty and five patients with GO undergoing orbital fat decompression for proptosis were analyzed by enzyme-linked immunosorbent assay. Results: The mean adiponectin concentration in samples from GO patients was 121.9 ± 29.5 ng/mL (mean ± standard deviation), versus 107.9 ± 26.6 ng/mL in the control group (P=0.20). Conclusion: This study was unable to demonstrate a statistically significant difference in adiponectin protein concentrations between the two studied groups.

Original languageEnglish (US)
Pages (from-to)1723-1726
Number of pages4
JournalClinical Ophthalmology
StatePublished - Aug 24 2013
Externally publishedYes


  • Graves' disease
  • Graves' orbitopathy

ASJC Scopus subject areas

  • Ophthalmology


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