Adherence and persistence of bimatoprost in prior latanoprost users

Vaishali Patel, Gail F. Schwartz, Pamela B. Landsman-Blumberg, Orsolya E. Lunacsek, William Wong

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: Bimatoprost 0.01%, a newer ophthalmic formulation, was hypothesized to improve adherence and persistence compared with the original bimatoprost 0.03% formulation. Study Design: A retrospective, observational cohort study was conducted that utilized a pharmacy claims database to examine the adherence to and persistence with prior latanoprost use among patients with glaucoma who were prescribed bimatoprost 0.01% or bimatoprost 0.03% for glaucoma treatment. Methods: Using pharmacy claims, adherence in 6035 bimatoprost 0.01% patients and 2705 bimatoprost 0.03% patients with prior latanoprost treatment was measured as a proportion of days covered (PDC). Persistence in 7780 bimatoprost 0.01% and 3454 bimatoprost 0.03% latanoprost-experienced patients was measured as the proportion of patients on continuous treatment for up to 12 months. Results: Adherence to bimatoprost 0.01% was significantly greater than to bimatoprost 0.03% (mean PDC, 0.74 vs 0.68; P <.001). Persistence with bimatoprost 0.01% (52%) was significantly greater than with bimatoprost 0.03% (46%). Analyses conducted by age group (aged <65 and ≥65 years) yielded similar results. Conclusions: In clinical practice, bimatoprost 0.01% demonstrated superior adherence and persistence compared with bimatoprost 0.03% in latanoprost-experienced patients.

Original languageEnglish (US)
Pages (from-to)e101-e107
JournalAmerican Journal of Pharmacy Benefits
Volume8
Issue number6
StatePublished - Nov 1 2016

ASJC Scopus subject areas

  • Business and International Management
  • Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
  • Decision Sciences (miscellaneous)

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