Abstract
We have isolated and cultured three distinct adenoviruses from wild gorillas. Phylogenetic analysis grouped the viruses with human adenovirus species C based on DNA polymerase, hexon, and E4ORF6 genes. The three wild gorilla adenoviruses clustered with the other species C captive gorilla adenoviruses, forming a branch separate from human and chimpanzee/bonobo adenoviruses. Animal sera to the three newly isolated viruses did not cross-neutralize, demonstrating serological distinctiveness. The human adenovirus 5 fiber knob blocked infection, suggesting use of the Coxsackie and Adenovirus Receptor. These viruses may provide viral vectors with properties distinct from chimpanzee adenovirus and human adenovirus vectors.
Original language | English (US) |
---|---|
Pages (from-to) | 119-123 |
Number of pages | 5 |
Journal | Virology |
Volume | 444 |
Issue number | 1-2 |
DOIs | |
State | Published - Sep 2013 |
Externally published | Yes |
Keywords
- Adenovirus
- Evolution
- Gorilla
- Non-human primate
- Viral vectors
ASJC Scopus subject areas
- Virology