TY - JOUR
T1 - Addressing the impact of urban exposure on the incidence of type 2 diabetes mellitus
T2 - The Peru MIGRANT Study
AU - Ruiz-Alejos, Andrea
AU - Carrillo-Larco, Rodrigo M.
AU - Miranda, J. Jaime
AU - Anderson, Cheryl A.M.
AU - Gilman, Robert H.
AU - Smeeth, Liam
AU - Bernabé-Ortiz, Antonio
N1 - Funding Information:
We are indebted to all of the participants from Ayacucho and Lima, who kindly agreed and completed their participation in the study. In addition, we would like to recognize and thank the commitment and hard work of all the fieldworkers, especially to Lilia Cabrera, Rosa Salirrosas and Marco Varela. The PERU MIGRANT Study baseline assessment work was funded by the Wellcome Trust (GR074833MA), and its first follow up was supported by Universidad Peruana Cayetano Heredia (Fondo Concursable No. 20205071009). This second follow up study was partly funded by the National Institute of Heart, Lung and Blood, National Institutes of Health through the GloCal Health Fellowship Program from the University of California Global Health Institute to AR-A, and partly under the contract No. HHSN268200900033C. JJM (205177/Z/16/Z), LS (098504/Z/12/Z) and AB-O (103994/Z/14/Z) are supported by Wellcome Trust. JJM acknowledges receiving additional support from DFID/MRC/Wellcome Global Health Trials (MR/M007405/1), Fogarty International Center (R21TW009982), International Development Research Center Canada (106887, 108167), Inter-American Institute for Global Change Research (IAI CRN3036), Medical Research Council (MR/P008984/1), National Heart, Lung and Blood Institute (5U01HL114180, 1UM1HL134590), National Institute of Mental Health (1U19MH098780), Swiss National Science Foundation (40P740-160366), and the World Diabetes Foundation (WDF15-1224).
Publisher Copyright:
© 2018 The Author(s).
PY - 2018/12/1
Y1 - 2018/12/1
N2 - The aim of this study was to estimate the incidence of T2DM in three population groups: rural, rural-to-urban migrants and urban dwellers. Data from the Peru MIGRANT Study was analysed. The baseline assessment was conducted in 2007-2008 using a single-stage random sample and further follow-up was undertaken in 2015-16. T2DM was defined based on fasting glucose and self-reported diagnosis. Poisson regression models and robust variance to account for cluster effects were used for reporting risk ratios (RR) and 95%CI. At baseline, T2DM prevalence was 8% in urban, 3.6% in rural-to-urban migrants and 1.5% in rural dwellers. After 7.7 (SD: 1.1) years, 6,076 person-years of follow-up, 61 new cases were identified. The incidence rates in the urban, migrant and rural groups were 1.6, 0.9 and 0.5 per 100 person-years, respectively. Relative to rural dwellers, a 4.3-fold higher risk (95%CI: 1.6-11.9) for developing T2DM was found in urban dwellers and 2.7-fold higher (95%CI: 1.1-6.8) in migrants with ≥30 years of urban exposure. Migration and urban exposure were found as significant risk factors for developing T2DM. Within-country migration is a sociodemographic phenomenon occurring worldwide; thus, it is necessary to disentangle the effect of urban exposure on non-healthy habits and T2DM development.
AB - The aim of this study was to estimate the incidence of T2DM in three population groups: rural, rural-to-urban migrants and urban dwellers. Data from the Peru MIGRANT Study was analysed. The baseline assessment was conducted in 2007-2008 using a single-stage random sample and further follow-up was undertaken in 2015-16. T2DM was defined based on fasting glucose and self-reported diagnosis. Poisson regression models and robust variance to account for cluster effects were used for reporting risk ratios (RR) and 95%CI. At baseline, T2DM prevalence was 8% in urban, 3.6% in rural-to-urban migrants and 1.5% in rural dwellers. After 7.7 (SD: 1.1) years, 6,076 person-years of follow-up, 61 new cases were identified. The incidence rates in the urban, migrant and rural groups were 1.6, 0.9 and 0.5 per 100 person-years, respectively. Relative to rural dwellers, a 4.3-fold higher risk (95%CI: 1.6-11.9) for developing T2DM was found in urban dwellers and 2.7-fold higher (95%CI: 1.1-6.8) in migrants with ≥30 years of urban exposure. Migration and urban exposure were found as significant risk factors for developing T2DM. Within-country migration is a sociodemographic phenomenon occurring worldwide; thus, it is necessary to disentangle the effect of urban exposure on non-healthy habits and T2DM development.
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U2 - 10.1038/s41598-018-23812-6
DO - 10.1038/s41598-018-23812-6
M3 - Article
C2 - 29615740
AN - SCOPUS:85044954804
SN - 2045-2322
VL - 8
JO - Scientific reports
JF - Scientific reports
IS - 1
M1 - 5512
ER -