Addressing the diagnostic and therapeutic dilemmas of ovarian immature teratoma: Report from a clinicopathologic consensus conference

Farzana Pashankar; Krisztina Hanley; Michelle Lockley; Sara Stoneham; Marisa R. Nucci; Miguel Reyes-Múgica; Esther Elishaev; Russell Vang; Jennifer Veneris; Heather Rytting; Thomas Olson; Kim Hazard; Al Covens; Rupali Arora; Deborah Billmire; Alyaa Al-Ibraheemi; Thomas M. Ulbright; Lindsay Frazier; Michelle S. Hirsch

doi:10.1016/j.ejca.2022.06.006

Addressing the diagnostic and therapeutic dilemmas of ovarian immature teratoma: Report from a clinicopathologic consensus conference

Farzana Pashankar, Krisztina Hanley, Michelle Lockley, Sara Stoneham, Marisa R. Nucci, Miguel Reyes-Múgica, Esther Elishaev, Russell Vang, Jennifer Veneris, Heather Rytting, Thomas Olson, Kim Hazard, Al Covens, Rupali Arora, Deborah Billmire, Alyaa Al-Ibraheemi, Thomas M. Ulbright, Lindsay Frazier, Michelle S. Hirsch

School of Medicine

Research output: Contribution to journal › Review article › peer-review

Abstract

Ovarian immature teratoma is a rare subtype of germ cell tumour that can be pure or associated with non-teratomatous germ cell tumour elements and is graded based on extent of the immature neuroectodermal component. Immature teratoma (IT) can also be associated with somatic differentiation in the form of sarcoma, carcinoma, or extensive immature neuroectodermal elements and may produce low levels of serum alpha-fetoprotein. Variable interpretation of these issues underlies diagnostic and management dilemmas, resulting in substantial practice differences between paediatric and adult women with IT. The Malignant Germ Cell International Consortium (MaGIC) convened oncologists, surgeons, and pathologists to address the following crucial clinicopathologic issues related to IT: (1) grading of IT, (2) definition and significance of ‘microscopic’ yolk sac tumour, (3) transformation to a somatic malignancy, and (4) interpretation of serum tumour biomarkers. This review highlights the discussion, conclusions, and suggested next steps from this clinicopathologic conference.

Original language	English (US)
Pages (from-to)	59-70
Number of pages	12
Journal	European Journal of Cancer
Volume	173
DOIs	https://doi.org/10.1016/j.ejca.2022.06.006
State	Published - Sep 2022

Keywords

Immature
Neuroectoderm
Ovarian
Primitive neuroectodermal tumour
Teratoma
Yolk sac tumour

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1016/j.ejca.2022.06.006

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Pashankar, F., Hanley, K., Lockley, M., Stoneham, S., Nucci, M. R., Reyes-Múgica, M., Elishaev, E., Vang, R., Veneris, J., Rytting, H., Olson, T., Hazard, K., Covens, A., Arora, R., Billmire, D., Al-Ibraheemi, A., Ulbright, T. M., Frazier, L., & Hirsch, M. S. (2022). Addressing the diagnostic and therapeutic dilemmas of ovarian immature teratoma: Report from a clinicopathologic consensus conference. European Journal of Cancer, 173, 59-70. https://doi.org/10.1016/j.ejca.2022.06.006

Pashankar, F, Hanley, K, Lockley, M, Stoneham, S, Nucci, MR, Reyes-Múgica, M, Elishaev, E, Vang, R, Veneris, J, Rytting, H, Olson, T, Hazard, K, Covens, A, Arora, R, Billmire, D, Al-Ibraheemi, A, Ulbright, TM, Frazier, L & Hirsch, MS 2022, 'Addressing the diagnostic and therapeutic dilemmas of ovarian immature teratoma: Report from a clinicopathologic consensus conference', European Journal of Cancer, vol. 173, pp. 59-70. https://doi.org/10.1016/j.ejca.2022.06.006

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title = "Addressing the diagnostic and therapeutic dilemmas of ovarian immature teratoma: Report from a clinicopathologic consensus conference",

abstract = "Ovarian immature teratoma is a rare subtype of germ cell tumour that can be pure or associated with non-teratomatous germ cell tumour elements and is graded based on extent of the immature neuroectodermal component. Immature teratoma (IT) can also be associated with somatic differentiation in the form of sarcoma, carcinoma, or extensive immature neuroectodermal elements and may produce low levels of serum alpha-fetoprotein. Variable interpretation of these issues underlies diagnostic and management dilemmas, resulting in substantial practice differences between paediatric and adult women with IT. The Malignant Germ Cell International Consortium (MaGIC) convened oncologists, surgeons, and pathologists to address the following crucial clinicopathologic issues related to IT: (1) grading of IT, (2) definition and significance of {\textquoteleft}microscopic{\textquoteright} yolk sac tumour, (3) transformation to a somatic malignancy, and (4) interpretation of serum tumour biomarkers. This review highlights the discussion, conclusions, and suggested next steps from this clinicopathologic conference.",

keywords = "Immature, Neuroectoderm, Ovarian, Primitive neuroectodermal tumour, Teratoma, Yolk sac tumour",

author = "Farzana Pashankar and Krisztina Hanley and Michelle Lockley and Sara Stoneham and Nucci, {Marisa R.} and Miguel Reyes-M{\'u}gica and Esther Elishaev and Russell Vang and Jennifer Veneris and Heather Rytting and Thomas Olson and Kim Hazard and Al Covens and Rupali Arora and Deborah Billmire and Alyaa Al-Ibraheemi and Ulbright, {Thomas M.} and Lindsay Frazier and Hirsch, {Michelle S.}",

note = "Funding Information: This work is supported by the Malignant Germ Cell International Consortium (MaGIC; www.magicconsortium.com ); funds from St. Baldrick's Consortium Research Grant were used for minimal administrative costs. Publisher Copyright: {\textcopyright} 2022 Elsevier Ltd",

year = "2022",

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doi = "10.1016/j.ejca.2022.06.006",

language = "English (US)",

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T2 - Report from a clinicopathologic consensus conference

AU - Pashankar, Farzana

AU - Hanley, Krisztina

AU - Lockley, Michelle

AU - Stoneham, Sara

AU - Nucci, Marisa R.

AU - Reyes-Múgica, Miguel

AU - Elishaev, Esther

AU - Vang, Russell

AU - Veneris, Jennifer

AU - Rytting, Heather

AU - Olson, Thomas

AU - Hazard, Kim

AU - Covens, Al

AU - Arora, Rupali

AU - Billmire, Deborah

AU - Al-Ibraheemi, Alyaa

AU - Ulbright, Thomas M.

AU - Frazier, Lindsay

AU - Hirsch, Michelle S.

N1 - Funding Information: This work is supported by the Malignant Germ Cell International Consortium (MaGIC; www.magicconsortium.com ); funds from St. Baldrick's Consortium Research Grant were used for minimal administrative costs. Publisher Copyright: © 2022 Elsevier Ltd

PY - 2022/9

Y1 - 2022/9

N2 - Ovarian immature teratoma is a rare subtype of germ cell tumour that can be pure or associated with non-teratomatous germ cell tumour elements and is graded based on extent of the immature neuroectodermal component. Immature teratoma (IT) can also be associated with somatic differentiation in the form of sarcoma, carcinoma, or extensive immature neuroectodermal elements and may produce low levels of serum alpha-fetoprotein. Variable interpretation of these issues underlies diagnostic and management dilemmas, resulting in substantial practice differences between paediatric and adult women with IT. The Malignant Germ Cell International Consortium (MaGIC) convened oncologists, surgeons, and pathologists to address the following crucial clinicopathologic issues related to IT: (1) grading of IT, (2) definition and significance of ‘microscopic’ yolk sac tumour, (3) transformation to a somatic malignancy, and (4) interpretation of serum tumour biomarkers. This review highlights the discussion, conclusions, and suggested next steps from this clinicopathologic conference.

AB - Ovarian immature teratoma is a rare subtype of germ cell tumour that can be pure or associated with non-teratomatous germ cell tumour elements and is graded based on extent of the immature neuroectodermal component. Immature teratoma (IT) can also be associated with somatic differentiation in the form of sarcoma, carcinoma, or extensive immature neuroectodermal elements and may produce low levels of serum alpha-fetoprotein. Variable interpretation of these issues underlies diagnostic and management dilemmas, resulting in substantial practice differences between paediatric and adult women with IT. The Malignant Germ Cell International Consortium (MaGIC) convened oncologists, surgeons, and pathologists to address the following crucial clinicopathologic issues related to IT: (1) grading of IT, (2) definition and significance of ‘microscopic’ yolk sac tumour, (3) transformation to a somatic malignancy, and (4) interpretation of serum tumour biomarkers. This review highlights the discussion, conclusions, and suggested next steps from this clinicopathologic conference.

KW - Immature

KW - Neuroectoderm

KW - Ovarian

KW - Primitive neuroectodermal tumour

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KW - Yolk sac tumour

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Addressing the diagnostic and therapeutic dilemmas of ovarian immature teratoma: Report from a clinicopathologic consensus conference

Abstract

Keywords

ASJC Scopus subject areas

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