Abstract
In vitro infectivity experiments were performed to assess the susceptibility of cells from various monkey species to HIV-1. T lymphocytes from pigtailed macaques, but not those from rhesus or cynomolgus monkeys, were susceptible to infection, but virus expression was limited. The majority of HIV-1 isolates were unable to productively infect pigtailed macaque cells. Inoculation of autologous, HIV-1 expressing cells led to establishment of persistent infection in pigtailed macaques as evidenced by recovery of infectious virus and development of virus-specific antibody responses.
Original language | English (US) |
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Pages (from-to) | 155-163 |
Number of pages | 9 |
Journal | Journal of Medical Primatology |
Volume | 23 |
Issue number | 2-3 |
State | Published - Feb 1994 |
Externally published | Yes |
ASJC Scopus subject areas
- Animal Science and Zoology
- General Veterinary