Adapalene 0.3% Gel Shows Efficacy for the Treatment of Atrophic Acne Scars

Manisha J. Loss, Sherry Leung, Anna Chien, Nabil Kerrouche, Alexander H. Fischer, Sewon Kang

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Introduction: Scarring is an unfortunate clinical outcome of acne. Current treatment options for atrophic acne scars are dominated by non-pharmacological, invasive procedures which may not be suitable or affordable to all patients. This phase II, single-center, open-label, exploratory study assessed the efficacy, safety and subject-reported outcomes of adapalene 0.3% gel in the treatment of atrophic acne scars. Methods: The study included subjects aged 18–50 years with past history of acne and moderate to severe facial atrophic acne scars. Subjects received adapalene 0.3% gel once daily for the first 4 weeks and twice daily for the following 20 weeks. Assessments were performed at baseline, day 10 and weeks 4, 8, 16 and 24, and at post-treatment follow-ups (weeks 36 and 48–72). Results: At week 24, investigator and subject assessments reported improvement in skin texture/atrophic scars in 50% and > 80% of subjects, respectively. Subjects were satisfied with the treatment and reported improvements in quality of life. Conclusion: Daily use of adapalene 0.3% gel for the treatment of atrophic acne scars showed promising clinical efficacy, a favorable tolerability profile, and improvement in quality of life. Funding: Nestlé Skin Health–Galderma R&D. Trial Registration: Identifier NCT01213199.

Original languageEnglish (US)
Pages (from-to)245-257
Number of pages13
JournalDermatology and Therapy
Issue number2
StatePublished - Jun 1 2018


  • Acne
  • Adapalene
  • Atrophic scars
  • Molecular markers
  • Scarring
  • Skin texture
  • Subject-reported outcome
  • Topical retinoids

ASJC Scopus subject areas

  • Dermatology


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