Acute tacrolimus overdose and treatment with phenytoin in liver transplant recipients.

Z. Karasu; A. Gurakar; J. Carlson; S. Pennington; B. Kerwin; H. Wright; B. Nour; A. Sebastian

Acute tacrolimus overdose and treatment with phenytoin in liver transplant recipients.

Z. Karasu, A. Gurakar, J. Carlson, S. Pennington, B. Kerwin, H. Wright, B. Nour, A. Sebastian

Research output: Contribution to journal › Article › peer-review

Abstract

As a potent immunosuppressive agent, Tacrolimus is widely used in organ transplantation. Although complications due to chronic Tacrolimus use are rather well recognized, little is known about acute overdose and its treatment. Phenytoin, an anti-convulsant agent, can induce the Cytochrome P450 enzyme in the liver, which metabolizes Tacrolimus. Therefore, it can be considered as a potential treatment option for acute Tacrolimus toxicity. We hereby report two cases of acute Tacrolimus overdose after Orthotopic Liver Transplantation and the treatment with Phenytoin. Probable mechanisms of metabolism and interactions of these two drugs are discussed and the literature is reviewed.

Original language	English (US)
Pages (from-to)	121-123
Number of pages	3
Journal	The Journal of the Oklahoma State Medical Association
Volume	94
Issue number	4
State	Published - Apr 2001
Externally published	Yes

ASJC Scopus subject areas

General Medicine

Cite this

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title = "Acute tacrolimus overdose and treatment with phenytoin in liver transplant recipients.",

abstract = "As a potent immunosuppressive agent, Tacrolimus is widely used in organ transplantation. Although complications due to chronic Tacrolimus use are rather well recognized, little is known about acute overdose and its treatment. Phenytoin, an anti-convulsant agent, can induce the Cytochrome P450 enzyme in the liver, which metabolizes Tacrolimus. Therefore, it can be considered as a potential treatment option for acute Tacrolimus toxicity. We hereby report two cases of acute Tacrolimus overdose after Orthotopic Liver Transplantation and the treatment with Phenytoin. Probable mechanisms of metabolism and interactions of these two drugs are discussed and the literature is reviewed.",

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AU - Karasu, Z.

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AU - Carlson, J.

AU - Pennington, S.

AU - Kerwin, B.

AU - Wright, H.

AU - Nour, B.

AU - Sebastian, A.

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N2 - As a potent immunosuppressive agent, Tacrolimus is widely used in organ transplantation. Although complications due to chronic Tacrolimus use are rather well recognized, little is known about acute overdose and its treatment. Phenytoin, an anti-convulsant agent, can induce the Cytochrome P450 enzyme in the liver, which metabolizes Tacrolimus. Therefore, it can be considered as a potential treatment option for acute Tacrolimus toxicity. We hereby report two cases of acute Tacrolimus overdose after Orthotopic Liver Transplantation and the treatment with Phenytoin. Probable mechanisms of metabolism and interactions of these two drugs are discussed and the literature is reviewed.

AB - As a potent immunosuppressive agent, Tacrolimus is widely used in organ transplantation. Although complications due to chronic Tacrolimus use are rather well recognized, little is known about acute overdose and its treatment. Phenytoin, an anti-convulsant agent, can induce the Cytochrome P450 enzyme in the liver, which metabolizes Tacrolimus. Therefore, it can be considered as a potential treatment option for acute Tacrolimus toxicity. We hereby report two cases of acute Tacrolimus overdose after Orthotopic Liver Transplantation and the treatment with Phenytoin. Probable mechanisms of metabolism and interactions of these two drugs are discussed and the literature is reviewed.

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Acute tacrolimus overdose and treatment with phenytoin in liver transplant recipients.

Abstract

ASJC Scopus subject areas

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