Acute pancreatitis with hyperlipemia. Evidence for a persistent defect in lipid metabolism

John L. Cameron; David M. Capuzzi; George D. Zuidema; Simeon Margolis

doi:10.1016/0002-9343(74)90480-X

Acute pancreatitis with hyperlipemia. Evidence for a persistent defect in lipid metabolism

John L. Cameron, David M. Capuzzi, George D. Zuidema, Simeon Margolis

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91 Scopus citations

Abstract

Hyperlipemia has been recognized with increasing frequency in patients with acute pancreatitis. The significance of this association is unknown. Twenty-two such patients were electively readmitted to a metabolic ward for study of their lipid metabolism during a quiescent period. Persistent fasting hypertriglyceridemia was found in 16 and abnormal lipoprotein electrophoretic patterns in 17. In addition, response to a lipid load was abnormal; in 20 of the 22 patients triglyceride levels rose over 500 mg/100 ml, and in 10 over 1,000 mg/100 ml. It is concluded that the lipid abnormalities detected during the acute attack of pancreatitis were not secondary but persisted long after the patient had recovered. Such underlying lipid abnormalities may play an intermediary role in the pathogenesis of pancreatitis.

Original language	English (US)
Pages (from-to)	482-487
Number of pages	6
Journal	The American journal of medicine
Volume	56
Issue number	4
DOIs	https://doi.org/10.1016/0002-9343(74)90480-X
State	Published - Apr 1974
Externally published	Yes

ASJC Scopus subject areas

General Medicine

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@article{07279a9bf9fe4ac4a182a2e884e1047c,

title = "Acute pancreatitis with hyperlipemia. Evidence for a persistent defect in lipid metabolism",

abstract = "Hyperlipemia has been recognized with increasing frequency in patients with acute pancreatitis. The significance of this association is unknown. Twenty-two such patients were electively readmitted to a metabolic ward for study of their lipid metabolism during a quiescent period. Persistent fasting hypertriglyceridemia was found in 16 and abnormal lipoprotein electrophoretic patterns in 17. In addition, response to a lipid load was abnormal; in 20 of the 22 patients triglyceride levels rose over 500 mg/100 ml, and in 10 over 1,000 mg/100 ml. It is concluded that the lipid abnormalities detected during the acute attack of pancreatitis were not secondary but persisted long after the patient had recovered. Such underlying lipid abnormalities may play an intermediary role in the pathogenesis of pancreatitis.",

author = "Cameron, {John L.} and Capuzzi, {David M.} and Zuidema, {George D.} and Simeon Margolis",

note = "Funding Information: From the Departments of Surgery and Medicine, The Johns Hopkins University, School of Medicine, Baltimore, Maryland 21205. This work was supported in part by U.S. Public Health Service Clinical Research Centers Grant RR35. Requests for reprints should be addressed to Dr. John L. Cameron, Department of Surgery, The Johns Hopkins Hospital, Baltimore, Maryland 21205. Manuscript accepted September 17, 1973. *Present address: Room 876, Maloney Building, Hospital of University of Pennsylvania, 3400 Spruce Street, Philadelphia, Pennsylvania 19104. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.",

year = "1974",

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doi = "10.1016/0002-9343(74)90480-X",

language = "English (US)",

volume = "56",

pages = "482--487",

journal = "The American journal of medicine",

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T1 - Acute pancreatitis with hyperlipemia. Evidence for a persistent defect in lipid metabolism

AU - Cameron, John L.

AU - Capuzzi, David M.

AU - Zuidema, George D.

AU - Margolis, Simeon

N1 - Funding Information: From the Departments of Surgery and Medicine, The Johns Hopkins University, School of Medicine, Baltimore, Maryland 21205. This work was supported in part by U.S. Public Health Service Clinical Research Centers Grant RR35. Requests for reprints should be addressed to Dr. John L. Cameron, Department of Surgery, The Johns Hopkins Hospital, Baltimore, Maryland 21205. Manuscript accepted September 17, 1973. *Present address: Room 876, Maloney Building, Hospital of University of Pennsylvania, 3400 Spruce Street, Philadelphia, Pennsylvania 19104. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.

PY - 1974/4

Y1 - 1974/4

N2 - Hyperlipemia has been recognized with increasing frequency in patients with acute pancreatitis. The significance of this association is unknown. Twenty-two such patients were electively readmitted to a metabolic ward for study of their lipid metabolism during a quiescent period. Persistent fasting hypertriglyceridemia was found in 16 and abnormal lipoprotein electrophoretic patterns in 17. In addition, response to a lipid load was abnormal; in 20 of the 22 patients triglyceride levels rose over 500 mg/100 ml, and in 10 over 1,000 mg/100 ml. It is concluded that the lipid abnormalities detected during the acute attack of pancreatitis were not secondary but persisted long after the patient had recovered. Such underlying lipid abnormalities may play an intermediary role in the pathogenesis of pancreatitis.

AB - Hyperlipemia has been recognized with increasing frequency in patients with acute pancreatitis. The significance of this association is unknown. Twenty-two such patients were electively readmitted to a metabolic ward for study of their lipid metabolism during a quiescent period. Persistent fasting hypertriglyceridemia was found in 16 and abnormal lipoprotein electrophoretic patterns in 17. In addition, response to a lipid load was abnormal; in 20 of the 22 patients triglyceride levels rose over 500 mg/100 ml, and in 10 over 1,000 mg/100 ml. It is concluded that the lipid abnormalities detected during the acute attack of pancreatitis were not secondary but persisted long after the patient had recovered. Such underlying lipid abnormalities may play an intermediary role in the pathogenesis of pancreatitis.

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JO - The American journal of medicine

JF - The American journal of medicine

IS - 4

ER -

Acute pancreatitis with hyperlipemia. Evidence for a persistent defect in lipid metabolism

Abstract

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