TY - JOUR
T1 - Acute pancreatitis patient registry to examine novel therapies in clinical experience (APPRENTICE)
T2 - An international, multicenter consortium for the study of acute pancreatitis
AU - Papachristou, Georgios I.
AU - Machicado, Jorge D.
AU - Stevens, Tyler
AU - Goenka, Mahesh Kumar
AU - Ferreira, Miguel
AU - Gutierrez, Silvia C.
AU - Singh, Vikesh K.
AU - Kamal, Ayesha
AU - Gonzalez-Gonzalez, Jose A.
AU - Pelaez-Luna, Mario
AU - Gulla, Aiste
AU - Zarnescu, Narcis O.
AU - Triantafyllou, Konstantinos
AU - Barbu, Sorin T.
AU - Easler, Jeffrey
AU - Ocampo, Carlos
AU - Capurso, Gabriele
AU - Archibugi, Livia
AU - Cote, Gregory A.
AU - Lambiase, Louis
AU - Kochhar, Rakesh
AU - Chua, Tiffany
AU - Tiwari, Subhash Ch
AU - Nawaz, Haq
AU - Park, Walter G.
AU - De-Madaria, Enrique
AU - Lee, Peter J.
AU - Wu, Bechien U.
AU - Greer, Phil J.
AU - Dugum, Mohannad
AU - Koutroumpakis, Efstratios
AU - Akshintala, Venkata
AU - Gougol, Amir
N1 - Publisher Copyright:
© 2017 Hellenic Society of Gastroenterology.
PY - 2017
Y1 - 2017
N2 - Background We have established a multicenter international consortium to better understand the natural history of acute pancreatitis (AP) worldwide and to develop a platform for future randomized clinical trials. Methods The AP patient registry to examine novel therapies in clinical experience (APPRENTICE) was formed in July 2014. Detailed web-based questionnaires were then developed to prospectively capture information on demographics, etiology, pancreatitis history, comorbidities, risk factors, severity biomarkers, severity indices, health-care utilization, management strategies, and outcomes of AP patients. Results Between November 2015 and September 2016, a total of 20 sites (8 in the United States, 5 in Europe, 3 in South America, 2 in Mexico and 2 in India) prospectively enrolled 509 AP patients. All data were entered into the REDCap (Research Electronic Data Capture) database by participating centers and systematically reviewed by the coordinating site (University of Pittsburgh). The approaches and methodology are described in detail, along with an interim report on the demographic results. Conclusion APPRENTICE, an international collaboration of tertiary AP centers throughout the world, has demonstrated the feasibility of building a large, prospective, multicenter patient registry to study AP. Analysis of the collected data may provide a greater understanding of AP and APPRENTICE will serve as a future platform for randomized clinical trials.
AB - Background We have established a multicenter international consortium to better understand the natural history of acute pancreatitis (AP) worldwide and to develop a platform for future randomized clinical trials. Methods The AP patient registry to examine novel therapies in clinical experience (APPRENTICE) was formed in July 2014. Detailed web-based questionnaires were then developed to prospectively capture information on demographics, etiology, pancreatitis history, comorbidities, risk factors, severity biomarkers, severity indices, health-care utilization, management strategies, and outcomes of AP patients. Results Between November 2015 and September 2016, a total of 20 sites (8 in the United States, 5 in Europe, 3 in South America, 2 in Mexico and 2 in India) prospectively enrolled 509 AP patients. All data were entered into the REDCap (Research Electronic Data Capture) database by participating centers and systematically reviewed by the coordinating site (University of Pittsburgh). The approaches and methodology are described in detail, along with an interim report on the demographic results. Conclusion APPRENTICE, an international collaboration of tertiary AP centers throughout the world, has demonstrated the feasibility of building a large, prospective, multicenter patient registry to study AP. Analysis of the collected data may provide a greater understanding of AP and APPRENTICE will serve as a future platform for randomized clinical trials.
KW - APPRENTICE
KW - Acute pancreatitis
KW - International multicenter consortium
KW - Methodology
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U2 - 10.20524/aog.2016.0109
DO - 10.20524/aog.2016.0109
M3 - Article
C2 - 28042246
AN - SCOPUS:85008240198
SN - 1108-7471
VL - 30
SP - 106
EP - 113
JO - Annals of Gastroenterology
JF - Annals of Gastroenterology
IS - 1
ER -