Acute pancreatitis: Experimental evaluation of steroid, albumin and Trasylol therapy

Taizo Kimura; George D. Zuidema; John L. Cameron

doi:10.1016/0002-9610(80)90178-6

Acute pancreatitis: Experimental evaluation of steroid, albumin and Trasylol therapy

Taizo Kimura, George D. Zuidema, John L. Cameron

School of Medicine

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Abstract

The efficacy of steroids, albumin and Trasylol administration in the treatment of experimental pancreatitis was evaluated. An isolated, ex vivo, perfused canine pancreas preparation was used and pancreatitis was initiated by free fatty acid infusion. Steroid administration worsened pancreatitis, Trasylol had no effect, and albumin was markedly effective in ameliorating pancreatitis. These results were interpreted as evidence against enzyme extravasation and for capillary injury as the initial step in the pathogenesis of pancreatitis.

Original language	English (US)
Pages (from-to)	403-408
Number of pages	6
Journal	American journal of surgery
Volume	140
Issue number	3
DOIs	https://doi.org/10.1016/0002-9610(80)90178-6
State	Published - 1980

ASJC Scopus subject areas

Surgery

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10.1016/0002-9610(80)90178-6

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title = "Acute pancreatitis: Experimental evaluation of steroid, albumin and Trasylol therapy",

abstract = "The efficacy of steroids, albumin and Trasylol administration in the treatment of experimental pancreatitis was evaluated. An isolated, ex vivo, perfused canine pancreas preparation was used and pancreatitis was initiated by free fatty acid infusion. Steroid administration worsened pancreatitis, Trasylol had no effect, and albumin was markedly effective in ameliorating pancreatitis. These results were interpreted as evidence against enzyme extravasation and for capillary injury as the initial step in the pathogenesis of pancreatitis.",

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AB - The efficacy of steroids, albumin and Trasylol administration in the treatment of experimental pancreatitis was evaluated. An isolated, ex vivo, perfused canine pancreas preparation was used and pancreatitis was initiated by free fatty acid infusion. Steroid administration worsened pancreatitis, Trasylol had no effect, and albumin was markedly effective in ameliorating pancreatitis. These results were interpreted as evidence against enzyme extravasation and for capillary injury as the initial step in the pathogenesis of pancreatitis.

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Acute pancreatitis: Experimental evaluation of steroid, albumin and Trasylol therapy

Abstract

ASJC Scopus subject areas

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