TY - JOUR
T1 - Acute kidney injury in a girl with ulcerative colitis and cytomegalovirus-induced focal segmental glomerular sclerosis
AU - Chirumamilla, Sankar R.
AU - He, Chun
AU - Racusen, Lorraine C.
AU - Scheimann, Ann O.
AU - Cuffari, Carmen
PY - 2013/2
Y1 - 2013/2
N2 - Background: Mesalamine or 5-aminosalicylic acid (5-ASA) has proven efficacy in treating patients with ulcerative colitis (UC). Although mesalamine is considered safe, it has been associated with acute interstitial nephritis and renal failure. Methods: Herein we present a case of a child with UC who developed acute renal failure on mesalamine therapy. Results: A 15-year-old African-American girl with well-controlled UC presented to the Johns Hopkins Hospital with a four-day history of high fever, malaise, generalized body aches, and productive non-bloody cough. Over the next three days, she developed acute renal failure with fluid retention, and elevated serum creatinine and blood urea nitrogen. A kidney biopsy showed drug induced acute interstitial nephritis and focal segmental glomerulosclerosis with viral inclusion bodies likely secondary to cytomegalovirus. Conclusion: When treating UC patients with a history of underlying renal disease, it is advised to carefully monitor renal function while on mesalamine therapy.
AB - Background: Mesalamine or 5-aminosalicylic acid (5-ASA) has proven efficacy in treating patients with ulcerative colitis (UC). Although mesalamine is considered safe, it has been associated with acute interstitial nephritis and renal failure. Methods: Herein we present a case of a child with UC who developed acute renal failure on mesalamine therapy. Results: A 15-year-old African-American girl with well-controlled UC presented to the Johns Hopkins Hospital with a four-day history of high fever, malaise, generalized body aches, and productive non-bloody cough. Over the next three days, she developed acute renal failure with fluid retention, and elevated serum creatinine and blood urea nitrogen. A kidney biopsy showed drug induced acute interstitial nephritis and focal segmental glomerulosclerosis with viral inclusion bodies likely secondary to cytomegalovirus. Conclusion: When treating UC patients with a history of underlying renal disease, it is advised to carefully monitor renal function while on mesalamine therapy.
KW - cytomegalovirus
KW - mesalamine
KW - renal failure
KW - ulcerative colitis
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U2 - 10.1007/s12519-011-0302-8
DO - 10.1007/s12519-011-0302-8
M3 - Article
C2 - 21874614
AN - SCOPUS:84873437532
SN - 1708-8569
VL - 9
SP - 84
EP - 86
JO - World Journal of Pediatrics
JF - World Journal of Pediatrics
IS - 1
ER -