Acute Effects of Aspirin and Acetaminophen on Renal Function

Paul H. Plotz, Robert P. Kimberly

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


The renal effects of aspirin and acetaminophen are minor. With a major overdose of acetaminophen, uncommonly renal failure may occur that cannot be ascribed to hepatic failure; its mechanism is unknown. Aspirin may cause a transient shedding of renal tubular cells, alterations in urate excretion, inhibition of spironolactone action, and, in certain clinical settings, a reversible decline in renal function manifested as a fall in glomerular filtration that may be accompanied by mild water, sodium, and potassium retention. Active systemic lupus erythematosus, advanced cirrhosis, and chronic renal insufficiency seem to predispose patients to the effects on renal function, and there is direct or indirect evidence in those conditions that prostaglandin synthesis is an important part of the body's attempt to preserve renal blood flow. Study of these effects has provided new insight into the way in which the kidneys may use prostaglandins to preserve renal function when it is threatened.

Original languageEnglish (US)
Pages (from-to)343-348
Number of pages6
JournalArchives of Internal Medicine
Issue number3
StatePublished - Feb 23 1981
Externally publishedYes

ASJC Scopus subject areas

  • Internal Medicine


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