Acute and chronic graft-versus-host disease

G. B. Vogelsang

Research output: Contribution to journalReview articlepeer-review

27 Scopus citations


Acute graft-versus-host disease is a two-step process. First, allorecognition of histocompatibility antigen activates T lymphocytes, which releases several cytokines, including interleukin-1 and tumor necrosis factor. Understanding of this activity resulted in new therapeutic approaches. Chronic graft-versus-host disease remains a very frequent and difficult problem to treat. Thalidomide was introduced as therapy for chronic graft-versus-host disease. Although basic research reported this year had no common theme, progress, was made in many areas.

Original languageEnglish (US)
Pages (from-to)276-281
Number of pages6
JournalCurrent opinion in oncology
Issue number2
StatePublished - Jan 1 1993

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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