Activity-dependent regulation of GABA expression in the visual cortex of adult monkeys

Stewart H.C. Hendry, Edward G. Jones

Research output: Contribution to journalArticlepeer-review

192 Scopus citations

Abstract

Levels of the inhibitory transmitter, GABA, and its synthesizing enzyme, GAD, appear to be regulated in the visual cortex of young adult monkeys in an activity-dependent manner. In monkeys subjected to monocular deprivation by eye removal, tetrodotoxin injection, or eyelid suture, the number of GABA and GAD immunoreactive neurons in deprived-eye columns of the cortex is reduced by up to 50%. This effect is unaccompanied by cell death and is reversible. After cessation of TTX injection or reopening of the eyes, the number of immunostained cells returns to normal. The effect appears after 4-5 days of eye removal or tetrodotoxin injection, but only after 7-16 weeks of eyelid suture. In the latter case, it is more severe in the younger monkeys. The reversible reduction in GABA and GAD immunostaining extends out of layer IVC into layer IVA and to neurons around but not in cytochrome oxidase periodicities of layer III. This may indicate selective vulnerability of GABA cells sensitive to high spatial frequency.

Original languageEnglish (US)
Pages (from-to)701-712
Number of pages12
JournalNeuron
Volume1
Issue number8
DOIs
StatePublished - Oct 1988
Externally publishedYes

ASJC Scopus subject areas

  • General Neuroscience

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