Activity-dependent extrinsic regulation of adult olfactory bulb and hippocampal neurogenesis

Dengke K. Ma, Woon Ryoung Kim, Guo Li Ming, Hongjun Song

Research output: Chapter in Book/Report/Conference proceedingConference contribution

105 Scopus citations


The adult mammalian brain continuously generates new neurons in the olfactory bulb and hippocampus throughout life. Adult neurogenesis, a highly dynamic process, has been shown to be exquisitely modulated by neuronal circuit activity at different stages, from proliferation of adult neural progenitors, to differentiation, maturation, integration, and survival of newborn neurons in the adult brain. Strategic activity-dependent addition of new neurons into the existing neuronal circuitry represents a prominent form of structural plasticity and may contribute to specific brain functions, such as learning, memory, and mood modulation. Here we review extrinsic mechanisms through which adult neurogenesis is regulated by environmental cues, physiological learning-related stimuli, and neuronal activities.

Original languageEnglish (US)
Title of host publicationAnnals of the New York Academy of Sciences
Number of pages10
StatePublished - Jul 2009

Publication series

NameAnnals of the New York Academy of Sciences
ISSN (Print)00778923
ISSN (Electronic)17496632


  • Adult stem cells
  • Neural activity
  • Neurogenesis
  • Neurotransmitter
  • Plasticity

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


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