Active cocaine immunization attenuates the discriminative properties of cocaine

Matthew W. Johnson, R. H. Ettinger

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


Anticocaine antibody, resulting from immunization with the cocaine-keyhole-limpet-hemocyanin (KLH) conjugate, weakened the ability of cocaine to act as a discriminative stimulus in rats. Subjects were given extensive training to discriminate 5.0 mg/kg of cocaine from saline prior to immunization. Several weeks following immunization with cocaine-KLH, subjects failed to reliably discriminate cocaine from saline. Nonimmunized control rats retained the ability to discriminate cocaine from saline throughout the experiment. These results further demonstrate that active immunization is effective in blunting cocaine effects. Immunized subjects were able to discriminate 20 mg/kg of cocaine, however, suggesting that anticocaine antibody may be overwhelmed by large cocaine doses.

Original languageEnglish (US)
Pages (from-to)163-167
Number of pages5
JournalExperimental and clinical psychopharmacology
Issue number2
StatePublished - Jan 1 2000
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health
  • Pharmacology (medical)


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