Activation of liver X receptor sensitizes human dendritic cells to inflammatory stimuli

Dániel Töröcsik, Mónika Baráth, Szilvia Benko, Lajos Széles, Balázs Dezso, Szilárd Póliska, Zoltán Hegyi, László Homolya, István Szatmári, Árpád Lányi, László Nagy

Research output: Contribution to journalArticlepeer-review

53 Scopus citations


Dendritic cells (DCs) respond to changes in their lipid environment by altering gene expression and immunophenotype. Some of these alterations are mediated via the nuclear receptor superfamily. However, little is known about the contribution of liver X receptor (LXR) to DC biology. In this study, we present a systematic analysis of LXR, activated by synthetic ligands or naturally occurring oxysterols in developing human monocyte-derived DCs.We found that LXRs are present and can be activated throughout DC differentiation in monocyte- and blood-derived DCs. Administration of LXR-specific natural or synthetic activators induced target gene expression accompanied by increased expression of DC maturation markers, such as CD80 and CD86. In mature DCs, LXR activation augmented the production of inflammatory cytokines IL-12, TNF-α, IL-6, and IL-8 and resulted in an increased capacity to activate CD4+ T cell proliferation upon ligation with TLR4 or TLR3 ligands. These effects appear to be underpinned by prolonged NF-κB signaling. Supporting such an inflammatory role, we found that LXR positive DCs are present in reactive lymph nodes in vivo. We propose that activation of LXR represents a novel lipid-signaling paradigm that alters the inflammatory response of human DCs.

Original languageEnglish (US)
Pages (from-to)5456-5465
Number of pages10
JournalJournal of Immunology
Issue number10
StatePublished - May 15 2010
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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