Abstract
Background - Platelet/endothelium interaction plays an important role in the pathophysiology of inflammation and atherosclerosis. The role of platelets for monocyte Chemotactic protein-1 (MCP-1) secretion and surface expression of intercellular adhesion molecule-1 (ICAM-1) on endothelial cells has been assessed. Methods and Results - Monolayers of human umbilical vein endothelial cells were incubated with nonstimulated or ADP-activated platelets for 6 hours, and secretion of MCP-1 and surface expression of ICAM- 1 were determined by ELISA and flow cytometry, respectively. In the presence of ADP-activated platelets, both MCP-1 secretion and ICAM-1 surface expression were significantly increased compared with nonstimulated platelets (P
Original language | English (US) |
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Pages (from-to) | 1164-1171 |
Number of pages | 8 |
Journal | Circulation |
Volume | 98 |
Issue number | 12 |
State | Published - Sep 22 1998 |
Externally published | Yes |
Keywords
- Cell adhesion molecules
- Endothelium
- Genes
- Platelets
- Proteins
ASJC Scopus subject areas
- Physiology
- Cardiology and Cardiovascular Medicine