@article{924cca0c71f4441bb30d11a468942c0e,
title = "Actin R256 Mono-methylation Is a Conserved Post-translational Modification Involved in Transcription",
abstract = "Nuclear actin and actin PTMs are poorly understood. Kumar et al. discover a system of actin PTMs similar to histone PTMs, including a conserved mark on nuclear actin (R256me1) with potential implications for transcription and human diseases.",
keywords = "INO80, PRMT5, TAAD, actin, actin PTMs, arginine monomethylation, nuclear actin, transcription",
author = "Ashok Kumar and Yuan Zhong and Amelie Albrecht and Sang, {Pau Biak} and Adrian Maples and Zhenan Liu and Vinesh Vinayachandran and Rohit Reja and Lee, {Chia Fang} and Ashutosh Kumar and Jiyuan Chen and Jing Xiao and Bongsoo Park and Jianjun Shen and Bin Liu and Person, {Maria D.} and Trybus, {Kathleen M.} and Zhang, {Kam Y.J.} and Pugh, {B. Franklin} and Kamm, {Kristine E.} and Milewicz, {Dianna M.} and Xuetong Shen and Prabodh Kapoor",
note = "Funding Information: We would like to thank Joi Holcomb for help with the graphical abstract; Collene Jeter, James T. Stull, John Xue, Hironuri Funabiki, Mayuk Guha, Jacek Gaertig, Marvin Mercado, Andre Bui, and John O'Brien for their helpful suggestions; and Sarah Adai and Chris Contreras for reading of the manuscript. P.K. is a Scholar for Cancer Research at Cancer Prevention Research Institute of Texas (CPRIT). Funding to P.K. is supported by CPRIT: RR160067, University of Texas STARs Program, and Start-up funds from The University of Texas Health Science Center at Tyler, TX. X.S. is supported by funds and grants from the United States National Cancer Institute (K22CA100017), American Cancer Society, the United States National Institute of General Medical Sciences (2R01GM093104), CPRIT: RP160242, the Center for Cancer Epigenetics, and the IRG program at MD Anderson Cancer Center. K.M.T. is funded by NIH HL110869. NIH grant R01ES013768 to B.F.P. also supported this work. This study also made use of the Science Park Flow Cytometry and Cell Imaging Core as well as NGS Core, supported by CPRIT Core Facility Support Grant RP120348. We thank RIKEN for computing resources on the HOKUSAI-GreatWave supercomputer used in this study. P.K. and X.S. designed the experiments; P.K. Ashok Kumar, Y.Z. A.A. P.B.S. A.M. Z.L. V.V. R.R. C.-F.L. Ashutosh Kumar, J.C. J.X. B.P. J.S. B.L. and M.D.P. executed the experiments; P.K. X.S. B.L. M.D.P. K.M.T. K.Y.J.Z. B.F.P. K.E.K. and D.M.M. analyzed the results; and P.K. and X.S. wrote the paper. B.F.P. has a financial interest in Piconic, LLC, which uses the ChIP-exo technology implemented in this study, and could potentially benefit from the outcomes of this research. Funding Information: We would like to thank Joi Holcomb for help with the graphical abstract; Collene Jeter, James T. Stull, John Xue, Hironuri Funabiki, Mayuk Guha, Jacek Gaertig, Marvin Mercado, Andre Bui, and John O{\textquoteright}Brien for their helpful suggestions; and Sarah Adai and Chris Contreras for reading of the manuscript. P.K. is a Scholar for Cancer Research at Cancer Prevention Research Institute of Texas (CPRIT). Funding to P.K. is supported by CPRIT : RR160067 , University of Texas STARs Program , and Start-up funds from The University of Texas Health Science Center at Tyler, TX. X.S. is supported by funds and grants from the United States National Cancer Institute ( K22CA100017 ), American Cancer Society , the United States National Institute of General Medical Sciences ( 2R01GM093104 ), CPRIT : RP160242 , the Center for Cancer Epigenetics , and the IRG program at MD Anderson Cancer Center. K.M.T. is funded by NIH HL110869 . NIH grant R01ES013768 to B.F.P. also supported this work. This study also made use of the Science Park Flow Cytometry and Cell Imaging Core as well as NGS Core, supported by CPRIT Core Facility Support Grant RP120348 . We thank RIKEN for computing resources on the HOKUSAI-GreatWave supercomputer used in this study. Publisher Copyright: {\textcopyright} 2020 The Authors",
year = "2020",
month = sep,
day = "29",
doi = "10.1016/j.celrep.2020.108172",
language = "English (US)",
volume = "32",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "13",
}