Acquisition of Vernal and Atopic Keratoconjunctivitis After Bone Marrow Transplantation

Khalid F. Tabbara, Amr Nassar, Syed Osman Ahmed, Fahad Al Mohareb, Mahmoud Aljurf

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Purpose: Vernal keratoconjunctivitis (VKC) and atopic keratoconjunctivitis (AKC) result from genetic and environmental factors. We present patients who had no history of atopic disorders before bone marrow transplantation (BMT) and who seem to have acquired VKC or AKC from their donors, who had atopic disorders. Design: Observational case series. Methods: The patients in this study were part of a cohort of patients who had undergone allogeneic hemapoietic stem cell transplantation (HSCT) from January 1997 through December 2007. Of 621 HSCT recipients, four recipients who were free of allergic disorders acquired VKC or AKC from their afflicted donors after HSCT. Each patient underwent complete ophthalmologic examination, determination of the total serum immunoglobulin (Ig) E, and conjunctival scrapings. Results: Four (0.64%) of 621 patients who had undergone HSCT acquired VKC or AKC after BMT. The donors had VKC or atopic dermatitis. In addition, in two of these four patients, asthma developed. One patient had elevated total serum IgE. Conjunctival scrapings of all four patients revealed the presence of eosinophils. One patient had concurrent graft-versus-host disease. Conclusions: VKC and AKC are systemic allergic disorders characterized by local ocular manifestations. This report suggests the possibility of the acquisition of VKC or AKC after BMT by adoptive transfer.

Original languageEnglish (US)
Pages (from-to)462-465
Number of pages4
JournalAmerican Journal of Ophthalmology
Issue number3
StatePublished - Sep 2008

ASJC Scopus subject areas

  • Ophthalmology


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