Acquired von Willebrand disease and multiple myeloma: A case report of a breast cancer survivor

Ning Jin, Farah F. Salahuddin, John A. Nesbitt

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1 Scopus citations


Acquired von Willebrand disease (aVWD) is rare disease and is associated with a variety of underlying diseases. We report a case of aVWD in the setting of multiple myeloma. The patient was a 63-year-old female with breast cancer in remission who was admitted for symptomatic anemia. She was diagnosed with multiple myeloma. She also had subcutaneous bleeding before admission. Laboratory studies revealed isolated prolongation of the activated partial thromboplastin time, which corrected in a mixing study. Her factor VIII activity, von Willebrand factor (VWF) Ag, and VWF activity were low. VWF multimer study confirmed the patient had aVWD. The treatment of aVWD is discussed in this article, including the treatment of underlying diseases, and acute management in emergent situations. An intriguing question in this case is whether the patient's multiple myeloma is a chemotherapy-induced hematological malignancy or a second primary malignancy.

Original languageEnglish (US)
Pages (from-to)890-893
Number of pages4
JournalBlood Coagulation and Fibrinolysis
Issue number8
StatePublished - Jan 1 2014


  • Acquired von Willebrand disease
  • Breast cancer
  • Chemotherapy
  • Multiple myeloma

ASJC Scopus subject areas

  • Hematology


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