Acquired echinocandin resistance in a Candida krusei isolate due to modification of glucan synthase

Jennifer Nielsen Kahn; Guillermo Garcia-Effron; Ming Jo Hsu; Steven Park; Kieren A. Marr; David S. Perlin

doi:10.1128/AAC.00067-07

Acquired echinocandin resistance in a Candida krusei isolate due to modification of glucan synthase

Jennifer Nielsen Kahn
, Guillermo Garcia-Effron
, Ming Jo Hsu
, Steven Park
, Kieren A. Marr
, David S. Perlin

Research output: Contribution to journal › Article › peer-review

94 Scopus citations

Abstract

A Candida krusei strain from a patient with acute myelogenous leukemia that displayed reduced susceptibility to echinocandin drugs contained a heterozygous mutation, T2080K, in FKS1. The resulting Phe655→Cys substitution altered the sensitivity of glucan synthase to echinocandin drugs, consistent with a common mechanism for echinocandin resistance in Candida spp.

Original language	English (US)
Pages (from-to)	1876-1878
Number of pages	3
Journal	Antimicrobial agents and chemotherapy
Volume	51
Issue number	5
DOIs	https://doi.org/10.1128/AAC.00067-07
State	Published - May 2007
Externally published	Yes

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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title = "Acquired echinocandin resistance in a Candida krusei isolate due to modification of glucan synthase",

abstract = "A Candida krusei strain from a patient with acute myelogenous leukemia that displayed reduced susceptibility to echinocandin drugs contained a heterozygous mutation, T2080K, in FKS1. The resulting Phe655→Cys substitution altered the sensitivity of glucan synthase to echinocandin drugs, consistent with a common mechanism for echinocandin resistance in Candida spp.",

author = "Kahn, \{Jennifer Nielsen\} and Guillermo Garcia-Effron and Hsu, \{Ming Jo\} and Steven Park and Marr, \{Kieren A.\} and Perlin, \{David S.\}",

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AU - Kahn, Jennifer Nielsen

AU - Garcia-Effron, Guillermo

AU - Hsu, Ming Jo

AU - Park, Steven

AU - Marr, Kieren A.

AU - Perlin, David S.

PY - 2007/5

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N2 - A Candida krusei strain from a patient with acute myelogenous leukemia that displayed reduced susceptibility to echinocandin drugs contained a heterozygous mutation, T2080K, in FKS1. The resulting Phe655→Cys substitution altered the sensitivity of glucan synthase to echinocandin drugs, consistent with a common mechanism for echinocandin resistance in Candida spp.

AB - A Candida krusei strain from a patient with acute myelogenous leukemia that displayed reduced susceptibility to echinocandin drugs contained a heterozygous mutation, T2080K, in FKS1. The resulting Phe655→Cys substitution altered the sensitivity of glucan synthase to echinocandin drugs, consistent with a common mechanism for echinocandin resistance in Candida spp.

UR - https://www.scopus.com/pages/publications/34248375952

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M3 - Article

C2 - 17325225

AN - SCOPUS:34248375952

SN - 0066-4804

VL - 51

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JO - Antimicrobial agents and chemotherapy

JF - Antimicrobial agents and chemotherapy

IS - 5

ER -

Acquired echinocandin resistance in a Candida krusei isolate due to modification of glucan synthase

Abstract

ASJC Scopus subject areas

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