TY - JOUR
T1 - Acquired echinocandin resistance in a Candida krusei isolate due to modification of glucan synthase
AU - Kahn, Jennifer Nielsen
AU - Garcia-Effron, Guillermo
AU - Hsu, Ming Jo
AU - Park, Steven
AU - Marr, Kieren A.
AU - Perlin, David S.
PY - 2007/5
Y1 - 2007/5
N2 - A Candida krusei strain from a patient with acute myelogenous leukemia that displayed reduced susceptibility to echinocandin drugs contained a heterozygous mutation, T2080K, in FKS1. The resulting Phe655→Cys substitution altered the sensitivity of glucan synthase to echinocandin drugs, consistent with a common mechanism for echinocandin resistance in Candida spp.
AB - A Candida krusei strain from a patient with acute myelogenous leukemia that displayed reduced susceptibility to echinocandin drugs contained a heterozygous mutation, T2080K, in FKS1. The resulting Phe655→Cys substitution altered the sensitivity of glucan synthase to echinocandin drugs, consistent with a common mechanism for echinocandin resistance in Candida spp.
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U2 - 10.1128/AAC.00067-07
DO - 10.1128/AAC.00067-07
M3 - Article
C2 - 17325225
AN - SCOPUS:34248375952
SN - 0066-4804
VL - 51
SP - 1876
EP - 1878
JO - Antimicrobial agents and chemotherapy
JF - Antimicrobial agents and chemotherapy
IS - 5
ER -