TY - JOUR
T1 - Acidified Feedings in Preterm Infants
T2 - A Historical and Physiological Perspective
AU - Barrett-Reis, Bridget
AU - Shakeel, Fauzia
AU - Dennis, Laura
AU - Baggs, Geraldine
AU - Masor, Marc L.
N1 - Publisher Copyright:
© 2022. The Author(s).
PY - 2023/1/1
Y1 - 2023/1/1
N2 - The use of acidified milk for feeding infants has a long, interesting history that appears to have developed from the use of buttermilk in Holland as early as the late 19th century for feeding infants with diarrhea. Physicians in the early 20th century assumed that the observed benefits were from buttermilk's acidity leading to the practice of acidifying infant formula. The historical and physiological perspective on the use of acidified infant formula is now especially relevant with the emergence of an acidified liquid human milk fortifier for preterm infants. Here, we review that history, with a deeper dive into the contemporary research on the use of acidified human milk fortifiers, the consequences for preterm infants, and the underlying physiological mechanisms.
AB - The use of acidified milk for feeding infants has a long, interesting history that appears to have developed from the use of buttermilk in Holland as early as the late 19th century for feeding infants with diarrhea. Physicians in the early 20th century assumed that the observed benefits were from buttermilk's acidity leading to the practice of acidifying infant formula. The historical and physiological perspective on the use of acidified infant formula is now especially relevant with the emergence of an acidified liquid human milk fortifier for preterm infants. Here, we review that history, with a deeper dive into the contemporary research on the use of acidified human milk fortifiers, the consequences for preterm infants, and the underlying physiological mechanisms.
KW - acidified feedings
KW - human milk fortifier
KW - infant formula
KW - premature infant
UR - http://www.scopus.com/inward/record.url?scp=85131681021&partnerID=8YFLogxK
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U2 - 10.1055/s-0042-1749166
DO - 10.1055/s-0042-1749166
M3 - Review article
C2 - 35640617
AN - SCOPUS:85131681021
SN - 0735-1631
VL - 40
SP - 141
EP - 148
JO - American journal of perinatology
JF - American journal of perinatology
IS - 2
ER -