Accuracy of doppler echocardiography in the hemodynamic assessment of pulmonary hypertension

Micah R. Fisher, Paul R. Forfia, Elzbieta Chamera, Traci Housten-Harris, Hunter C. Champion, Reda E. Girgis, Mary C. Corretti, Paul M. Hassoun

Research output: Contribution to journalArticlepeer-review

661 Scopus citations


Rationale: Transthoracic Doppler echocardiography is recommended for screening for the presence of pulmonary hypertension (PH). However, some recent studies have suggested that Doppler echocardiographic pulmonary artery pressure estimates may frequently be inaccurate. Objectives: Evaluate the accuracy of Doppler echocardiography for estimating pulmonary artery pressure and cardiac output. Methods: We conducted a prospective study on patients with various forms of PH who underwent comprehensive Doppler echocardiography within 1 hour of a clinically indicated right-heart catheterization to compare noninvasive hemodynamic estimates with inva- sively measured values. Measurements and Main Results: A total of 65 patients completed the study protocol. Using Bland-Altman analytic methods, the bias for the echocardiographic estimates of the pulmonary artery systolic pressure was -0.6 mm Hg with 95% limits of agreement ranging from +38.8 to -40.0 mm Hg. Doppler echocardiography was inaccurate (defined as being greater than ±10 mm Hg of the invasive measurement) in 48% of cases. Overestimation and underestimation of pulmonary artery systolic pressure by Doppler echocardiog- raphy occurred with a similar frequency (16 vs. 15 instances, respectively). The magnitude of pressure underestimation was greater than overestimation (-30 ± 16 vs. + 19 ± 11 mm Hg; P = 0.03); underestimates by Doppler also led more often to misclassification of the severity of the PH. For cardiac output measurement, the bias was -0.1 L/min with 95% limits of agreement ranging from 12.2 to -2.4 L/min. Conclusions: Doppler echocardiography may frequently be inaccurate in estimating pulmonary artery pressure and cardiac output in patients being evaluated for PH.

Original languageEnglish (US)
Pages (from-to)615-621
Number of pages7
JournalAmerican journal of respiratory and critical care medicine
Issue number7
StatePublished - Apr 1 2009


  • Accuracy
  • Cardiac output
  • Echocardiography
  • Pulmonary hypertension
  • Pulmonary systolic pressure

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine


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