TY - JOUR
T1 - Acceptability of a dapivirine gel administered rectally to HIV-1 seronegative adults (MTN-033 study)
AU - MTN-033 Protocol Team
AU - Bauermeister, José A.
AU - Tingler, Ryan C.
AU - Johnson, Sherri
AU - Macagna, Nicole
AU - Lucas, Jonathan
AU - Dominguez-Islas, Clara
AU - Szydlo, Daniel
AU - Ngo, Julie
AU - Jacobson, Cindy E.
AU - Kramzer, Lindsay
AU - Singh, Devika
AU - Dezzutti, Charlene S.
AU - Kunjara Na Ayudhya, Ratiya Pamela
AU - Piper, Jeanna
AU - Devlin, Bríd
AU - Hendrix, Craig W.
AU - Ho, Ken
N1 - Publisher Copyright:
© 2021 The Guilford Press.
PY - 2021/10
Y1 - 2021/10
N2 - We triangulated quantitative and qualitative assessments to evaluate participants’ acceptability of 0.05% dapivirine rectal microbicide (RM) gel administered via two separate modalities (a rectal applicator and an artificial phallus for use as a coital simulation device) as part of a Phase I trial (N = 14) among men who have sex with men (MSM) randomized using a 1:1 ratio. Overall, participants reported favorable acceptability of the gel (n = 11; 78.6%), the same or more at the end of the study compared to when they started the study. Additionally, when discussing their preferred administration modality, they noted that both methods had positive qualities but also potential areas of improvement. Our findings underscore the need to create multiple delivery methods for a future microbicide gel (i.e., with and without the need for an applicator) and highlight the importance of offering MSM choices in how biomedical HIV prevention strategies are delivered.
AB - We triangulated quantitative and qualitative assessments to evaluate participants’ acceptability of 0.05% dapivirine rectal microbicide (RM) gel administered via two separate modalities (a rectal applicator and an artificial phallus for use as a coital simulation device) as part of a Phase I trial (N = 14) among men who have sex with men (MSM) randomized using a 1:1 ratio. Overall, participants reported favorable acceptability of the gel (n = 11; 78.6%), the same or more at the end of the study compared to when they started the study. Additionally, when discussing their preferred administration modality, they noted that both methods had positive qualities but also potential areas of improvement. Our findings underscore the need to create multiple delivery methods for a future microbicide gel (i.e., with and without the need for an applicator) and highlight the importance of offering MSM choices in how biomedical HIV prevention strategies are delivered.
KW - Behavioral congruence
KW - HIV
KW - HIV prevention
KW - Microbicides
KW - Rectal
UR - http://www.scopus.com/inward/record.url?scp=85118131646&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85118131646&partnerID=8YFLogxK
U2 - 10.1521/AEAP.2021.33.5.361
DO - 10.1521/AEAP.2021.33.5.361
M3 - Article
AN - SCOPUS:85118131646
SN - 0899-9546
VL - 33
SP - 361
EP - 376
JO - AIDS Education and Prevention
JF - AIDS Education and Prevention
IS - 5
ER -