Accelerating aging research: How can we measure the rate of biologic aging?

Joseph B. Margolick; Luigi Ferrucci

doi:10.1016/j.exger.2015.02.009

Accelerating aging research: How can we measure the rate of biologic aging?

Joseph B. Margolick, Luigi Ferrucci

Bloomberg School of Public Health

Research output: Contribution to journal › Comment/debate › peer-review

26 Scopus citations

Abstract

Claims of accelerated or premature aging are frequently made. However, the lack of standard criteria for measuring speed of aging makes such claims highly questionable. Because of fundamental gaps in our current understanding of the biological mechanisms of aging, the development of specific phenotypes that are due to aging is difficult and such phenotypes can only be derived by observational data. However, a clinical phenotype of aging exists that is experienced by all living individuals and is pervasive across multiple physiologic systems. Characterizing this phenotype can serve as a basis for measuring the speed of aging, and can facilitate a better understanding of the aging process and its interaction with chronic diseases.

Original language	English (US)
Pages (from-to)	78-80
Number of pages	3
Journal	Experimental Gerontology
Volume	64
DOIs	https://doi.org/10.1016/j.exger.2015.02.009
State	Published - Apr 1 2015

Keywords

Accelerated aging
Age-associated diseases
Aging phenotype
Gerosciences

ASJC Scopus subject areas

Biochemistry
Aging
Molecular Biology
Genetics
Endocrinology
Cell Biology

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10.1016/j.exger.2015.02.009

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title = "Accelerating aging research: How can we measure the rate of biologic aging?",

abstract = "Claims of accelerated or premature aging are frequently made. However, the lack of standard criteria for measuring speed of aging makes such claims highly questionable. Because of fundamental gaps in our current understanding of the biological mechanisms of aging, the development of specific phenotypes that are due to aging is difficult and such phenotypes can only be derived by observational data. However, a clinical phenotype of aging exists that is experienced by all living individuals and is pervasive across multiple physiologic systems. Characterizing this phenotype can serve as a basis for measuring the speed of aging, and can facilitate a better understanding of the aging process and its interaction with chronic diseases.",

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N2 - Claims of accelerated or premature aging are frequently made. However, the lack of standard criteria for measuring speed of aging makes such claims highly questionable. Because of fundamental gaps in our current understanding of the biological mechanisms of aging, the development of specific phenotypes that are due to aging is difficult and such phenotypes can only be derived by observational data. However, a clinical phenotype of aging exists that is experienced by all living individuals and is pervasive across multiple physiologic systems. Characterizing this phenotype can serve as a basis for measuring the speed of aging, and can facilitate a better understanding of the aging process and its interaction with chronic diseases.

AB - Claims of accelerated or premature aging are frequently made. However, the lack of standard criteria for measuring speed of aging makes such claims highly questionable. Because of fundamental gaps in our current understanding of the biological mechanisms of aging, the development of specific phenotypes that are due to aging is difficult and such phenotypes can only be derived by observational data. However, a clinical phenotype of aging exists that is experienced by all living individuals and is pervasive across multiple physiologic systems. Characterizing this phenotype can serve as a basis for measuring the speed of aging, and can facilitate a better understanding of the aging process and its interaction with chronic diseases.

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KW - Age-associated diseases

KW - Aging phenotype

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Accelerating aging research: How can we measure the rate of biologic aging?

Abstract

Keywords

ASJC Scopus subject areas

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