Accelerated discovery via a whole-cell model

Jayodita C. Sanghvi, Sergi Regot, Silvia Carrasco, Jonathan R. Karr, Miriam V. Gutschow, Benjamin Bolival, Markus W. Covert

Research output: Contribution to journalArticlepeer-review

42 Scopus citations


To test the promise of whole-cell modeling to facilitate scientific inquiry, we compared growth rates simulated in a whole-cell model with experimental measurements for all viable single-gene disruption Mycoplasma genitalium strains. Discrepancies between simulations and experiments led to predictions about kinetic parameters of specific enzymes that we subsequently validated. These findings represent, to our knowledge, the first application of whole-cell modeling to accelerate biological discovery.

Original languageEnglish (US)
Pages (from-to)1192-1195
Number of pages4
JournalNature Methods
Issue number12
StatePublished - Dec 2013
Externally publishedYes

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Cell Biology


Dive into the research topics of 'Accelerated discovery via a whole-cell model'. Together they form a unique fingerprint.

Cite this