Absence of Epstein-Barr viral RNA in lymphomatoid papulosis

M. E. Kadin, E. C. Vonderheid, L. M. Weiss

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


Epstein-Barr virus (EBV) recently has been implicated in the pathogenesis of Hodgkin's disease (HD). Lymphomatoid papulosis (LyP) is a premalignant cutaneous lymphoproliferative disorder which shares several characteristics with HD. The hypothesis has been made that EBV may be associated with the pathogenesis of LyP. We therefore examined 17 skin biopsy specimens and two lymph nodes from nine patients with LyP for EBV RNA using the highly sensitive and specific EBER method. In all specimens, the large atypical cells were negative for EBV while poly T studies confirmed the presence of adequate RNA for detection of EBER. The negative EBER results were confirmed in seven LyP patients whose biopsies were also stained for latent membrane protein (LMP-1). Interestingly, one patient with clonally related LyP and HD had no EBV RNA detected in any specimen. We conclude that EBV is unlikely to be an important aetiological agent in LyP. If confirmed in other patients, HD associated with LyP may have a different aetiology from HD arising de novo.

Original languageEnglish (US)
Pages (from-to)145-148
Number of pages4
JournalJournal of Pathology
Issue number2
StatePublished - 1993
Externally publishedYes


  • Epstein-Barr virus
  • Hodgkin's disease
  • Lymphomatoid papulosis
  • RNA

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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