Absence of deleterious palladin mutations in patients with familial pancreatic cancer

Alison P. Klein; Michael Borges; Margaret Griffith; Kieran Brune; Seung Mo Hong; Noriyuki Omura; Ralph H. Hruban; Michael Goggins

doi:10.1158/1055-9965.EPI-09-0056

Absence of deleterious palladin mutations in patients with familial pancreatic cancer

Alison P. Klein, Michael Borges, Margaret Griffith, Kieran Brune, Seung Mo Hong, Noriyuki Omura, Ralph H. Hruban, Michael Goggins

School of Medicine

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

It has been reported that germline mutations in the palladin gene (PALLD) cause the familial aggregation of pancreatic cancer, but the evidence is weak and controversial. We sequenced the coding regions of PALLD in 48 individuals with familial pancreatic cancer. We did not find any deleterious mutations and find no evidence to implicate mutations in PALLD as a cause of familial pancreatic cancer.

Original language	English (US)
Pages (from-to)	1328-1330
Number of pages	3
Journal	Cancer Epidemiology Biomarkers and Prevention
Volume	18
Issue number	4
DOIs	https://doi.org/10.1158/1055-9965.EPI-09-0056
State	Published - Apr 2009

ASJC Scopus subject areas

Epidemiology
Oncology

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abstract = "It has been reported that germline mutations in the palladin gene (PALLD) cause the familial aggregation of pancreatic cancer, but the evidence is weak and controversial. We sequenced the coding regions of PALLD in 48 individuals with familial pancreatic cancer. We did not find any deleterious mutations and find no evidence to implicate mutations in PALLD as a cause of familial pancreatic cancer.",

author = "Klein, {Alison P.} and Michael Borges and Margaret Griffith and Kieran Brune and Hong, {Seung Mo} and Noriyuki Omura and Hruban, {Ralph H.} and Michael Goggins",

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AU - Klein, Alison P.

AU - Borges, Michael

AU - Griffith, Margaret

AU - Brune, Kieran

AU - Hong, Seung Mo

AU - Omura, Noriyuki

AU - Hruban, Ralph H.

AU - Goggins, Michael

PY - 2009/4

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N2 - It has been reported that germline mutations in the palladin gene (PALLD) cause the familial aggregation of pancreatic cancer, but the evidence is weak and controversial. We sequenced the coding regions of PALLD in 48 individuals with familial pancreatic cancer. We did not find any deleterious mutations and find no evidence to implicate mutations in PALLD as a cause of familial pancreatic cancer.

AB - It has been reported that germline mutations in the palladin gene (PALLD) cause the familial aggregation of pancreatic cancer, but the evidence is weak and controversial. We sequenced the coding regions of PALLD in 48 individuals with familial pancreatic cancer. We did not find any deleterious mutations and find no evidence to implicate mutations in PALLD as a cause of familial pancreatic cancer.

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JO - Cancer Epidemiology Biomarkers and Prevention

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Absence of deleterious palladin mutations in patients with familial pancreatic cancer

Abstract

ASJC Scopus subject areas

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