Abstract
This study evaluated the efficacy and mode of action of rapamycin (RPM) in a model of accelerated (24-hr) rejection of LBNF1 cardiac allografts in specifically sensitized LEW rats. RPM treatment (0.25 mg/kg/day i.p.) between the day of sensitizing skin grafts (day −7) and subsequent heart (day 0) transplantation (Tx), abrogated fulminant rejection and prolonged cardiac allograft survival to 46±22 days (mean±SD, P
Original language | English (US) |
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Pages (from-to) | 933-941 |
Number of pages | 9 |
Journal | Transplantation |
Volume | 57 |
Issue number | 6 |
State | Published - 1994 |
Externally published | Yes |
ASJC Scopus subject areas
- Transplantation
- Immunology