Abrogation by rapamycin of accelerated rejection in sensitized rats by inhibition of alloantibody responses and selective suppression of intragraft mononuclear and endothelial cell activation, cytokine production, and cell adhesion

Georg Schmidbauer; Wayne W. Hancock; Barbara Wasowska; Alison M. Badger; Jerzy W. Kupiec-Weglinski

Abrogation by rapamycin of accelerated rejection in sensitized rats by inhibition of alloantibody responses and selective suppression of intragraft mononuclear and endothelial cell activation, cytokine production, and cell adhesion

Georg Schmidbauer, Wayne W. Hancock, Barbara Wasowska, Alison M. Badger, Jerzy W. Kupiec-Weglinski

Research output: Contribution to journal › Article › peer-review

Abstract

This study evaluated the efficacy and mode of action of rapamycin (RPM) in a model of accelerated (24-hr) rejection of LBNF1 cardiac allografts in specifically sensitized LEW rats. RPM treatment (0.25 mg/kg/day i.p.) between the day of sensitizing skin grafts (day −7) and subsequent heart (day 0) transplantation (Tx), abrogated fulminant rejection and prolonged cardiac allograft survival to 46±22 days (mean±SD, P

Original language	English (US)
Pages (from-to)	933-941
Number of pages	9
Journal	Transplantation
Volume	57
Issue number	6
State	Published - 1994
Externally published	Yes

ASJC Scopus subject areas

Transplantation
Immunology

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Abrogation by rapamycin of accelerated rejection in sensitized rats by inhibition of alloantibody responses and selective suppression of intragraft mononuclear and endothelial cell activation, cytokine production, and cell adhesion. / Schmidbauer, Georg; Hancock, Wayne W.; Wasowska, Barbara et al.
In: Transplantation, Vol. 57, No. 6, 1994, p. 933-941.

Research output: Contribution to journal › Article › peer-review

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AU - Badger, Alison M.

AU - Kupiec-Weglinski, Jerzy W.

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Abrogation by rapamycin of accelerated rejection in sensitized rats by inhibition of alloantibody responses and selective suppression of intragraft mononuclear and endothelial cell activation, cytokine production, and cell adhesion

Abstract

ASJC Scopus subject areas

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