ABO blood group and risk of epithelial ovarian cancer within the Ovarian Cancer Association Consortium

Elizabeth M. Poole, Margaret A. Gates, Brigit A. High, Stephen J. Chanock, Daniel W. Cramer, Julie M. Cunningham, Brooke L. Fridley, Simon A. Gayther, Ellen L. Goode, Edwin S. Iversen, Jolanta Lissowska, Rachel T.Palmieri Weber, Paul D.P. Pharoah, Catherine M. Phelan, Susan J. Ramus, Joellen M. Schildkraut, Rebecca Sutphen, Ya Yu Tsai, Jonathan Tyrer, Robert A. VierkantNicolas Wentzensen, Hannah P. Yang, Kathryn L. Terry, Shelley S. Tworoger

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


Purpose Previous studies have examined the association between ABO blood group and ovarian cancer risk, with inconclusive results. Methods In eight studies participating in theOvarianCancer Association Consortium, we determined ABO blood groups and diplotypes by genotyping 3 SNPs in the ABO locus. Odds ratios and 95 % confidence intervals were calculated in each study using logistic regression; individual study results were combined using random effects meta-analysis. Results Compared to blood group O, the A blood group was associated with a modestly increased ovarian cancer risk: (OR: 1.09; 95 % CI: 1.01-1.18; p = 0.03). In diplotype analysis, the AO, but not the AA diplotype, was associated with increased risk (AO: OR: 1.11; 95 % CI: 1.01-1.22; p = 0.03; AA: OR: 1.03; 95 % CI:0.87-1.21; p = 0.76). Neither AB nor the B blood groups were associated with risk. Results were similar across ovarian cancer histologic subtypes. Conclusion Consistent with most previous reports, the A blood type was associated modestly with increased ovarian cancer risk in this large analysis of multiple studies of ovarian cancer. Future studies investigating potential biologic mechanisms are warranted.

Original languageEnglish (US)
Pages (from-to)1805-1810
Number of pages6
JournalCancer Causes and Control
Issue number11
StatePublished - Nov 2012
Externally publishedYes


  • ABO blood group
  • Genetic epidemiology
  • Ovarian Cancer Association Consortium (OCAC)
  • Ovarian cancer

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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