ABO blood group and cardiovacular disease the Framingham study

R. J. Garrison, R. J. Havlik, R. B. Harris, M. Feinleib, W. B. Kannel, S. J. Padgett

Research output: Contribution to journalArticlepeer-review

66 Scopus citations


Following determination of ABO blood type at the sixth biennial examination, the Framingham Heart Study cohort was followed for the occurrence of cardiovascular events for a period of 10 years. A significant association was found between blood type and intermittent claudication, with blood group O showing the lowest rates. Slight but non-significant excesses for certain other CHD events were also found in non-O individuals. Serum cholesterol showed marginally significant but consistent elevations in non-O subjects but the increased risk in non-O individuals was found to occur independently of the known intermittent claudication risk factors. Since the observed relationship between blood type and intermittent claudication occurs independently of the usual atherosclerotic risk factors, blood type, possibly through an effect on clotting, should be considered in the pathogenesis of intermittent claudication.

Original languageEnglish (US)
Pages (from-to)311-318
Number of pages8
Issue number2-3
StatePublished - 1976
Externally publishedYes


  • ABO blood group
  • Atherosclerosis
  • Blood clotting
  • Cardiovascular disease
  • Epidemiology
  • Human genetics
  • Intermittent claudication

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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