Abnormalities in corticotropin-releasing factor (CRF) in neurodegenerative diseases

Errol B. De Souza; Garth Bissette; Peter J. Whitehouse; Richard E. Powers; Donald L. Price; Wylie Vale; Charles B. Nemeroff

doi:10.1201/9781351070935

Abnormalities in corticotropin-releasing factor (CRF) in neurodegenerative diseases

Errol B. De Souza, Garth Bissette, Peter J. Whitehouse, Richard E. Powers, Donald L. Price, Wylie Vale, Charles B. Nemeroff

School of Medicine

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

The pathologies occumng in various neurodegenerative disorders are associated with dysfunction and death of neurons in a variety of cell populations, including cholinergic, monoaminergic, and peptidergic systems. Corticotropin-releasing factor (CRF) has been demonstrated to have a broad distribution in the central nervous system (CNS) and to produce a wide spectrum of autonomic, electrophysiologic, and behavioral effects characteristic of a neurotransmitter in the CNS (see various chapters). Recent clinical data suggest that CRF may be of relevance in endocrine, psychiatric, and neurologic illnesses. In this chapter, we summarize some of the data from our recent studies examining changes in pre- and postsynaptic markers for CRF in various brain regions in a variety of neurodegenerative disorders including Alzheimer’s disease (AD), Parkinson’s Disease (PD), progressive supranuclear palsy (PSP), and Huntington’s Disease (HD).

Original language	English (US)
Title of host publication	Corticotropin-Releasing Factor
Subtitle of host publication	Basic and Clinical Studies of a Neuropeptide
Publisher	CRC Press
Pages	335-349
Number of pages	15
ISBN (Electronic)	9781351079389
ISBN (Print)	0849345502, 9781315891835
DOIs	https://doi.org/10.1201/9781351070935
State	Published - Jan 1 2018

ASJC Scopus subject areas

General Pharmacology, Toxicology and Pharmaceutics
General Medicine

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10.1201/9781351070935

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AU - Powers, Richard E.

AU - Price, Donald L.

AU - Vale, Wylie

AU - Nemeroff, Charles B.

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Abnormalities in corticotropin-releasing factor (CRF) in neurodegenerative diseases

Abstract

ASJC Scopus subject areas

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