Abnormal vascular relaxation in essential hypertension

L. Rodríguez-Mañas, J. J. Solano, C. Cano, J. I. González-Montalvo, Michel Safar, Rachelle Laforce, Diane M. Becker, Lewis C. Becker, John G. Kral, Julio A. Panza

Research output: Contribution to journalLetterpeer-review


To the Editor: The article by Panza et al. (July 5 issue)1 reported an impairment of endothelium-dependent vascular relaxation induced by acetylcholine in patients with essential hypertension. In the Discussion section the authors argued against the possibility of a role for hyperpolarizing factor in this observed phenomenon. However, hyperpolarizing factor is also a relaxing factor released by acetylcholine,2 probably acting on a different subtype of muscarinic receptor.3 It has been speculated that this factor may play a part in the endothelium-dependent response to acetylcholine.3 It might be possible to study the endothelial relaxing factor or factors that mediate the different.

Original languageEnglish (US)
Pages (from-to)1772-1773
Number of pages2
JournalNew England Journal of Medicine
Issue number25
StatePublished - Dec 20 1990
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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