Abnormal smooth pursuit eye movements in schizophrenic patients are associated with cerebral glucose metabolism in oculomotor regions

David E. Ross; Gunvant K. Thaker; Henry H. Holcomb; Nicola G. Cascella; Deborah R. Medoff; Carol A. Tamminga

doi:10.1016/0165-1781(95)02724-B

Abnormal smooth pursuit eye movements in schizophrenic patients are associated with cerebral glucose metabolism in oculomotor regions

David E. Ross, Gunvant K. Thaker, Henry H. Holcomb, Nicola G. Cascella, Deborah R. Medoff, Carol A. Tamminga

Research output: Contribution to journal › Article › peer-review

48 Scopus citations

Abstract

The purpose of this study was to test the hypothesis that abnormal smooth pursuit eye movements in schizophrenic patients would be related to cerebral glucose utilization in specific oculomotor regions. Eye movements were assessed with infrared oculography in 11 unmedicated schizophrenic patients and 13 normal comparison subjects. For the patients only, regional cerebral metabolic rate of glucose utilization was measured with positron emission tomography. Abnormal pursuit tracking in the patients was associated with relatively decreased metabolism in the frontal eye fields and increased metabolism in the caudate nuclei. The results are consistent with the hypothesis that these cerebral regions are involved in the pathophysiology of abnormal pursuit as related parts of a cortical-subcortical oculomotor circuit.

Original language	English (US)
Pages (from-to)	53-67
Number of pages	15
Journal	Psychiatry research
Volume	58
Issue number	1
DOIs	https://doi.org/10.1016/0165-1781(95)02724-B
State	Published - Sep 8 1995
Externally published	Yes

Keywords

Caudate nucleus
Frontal eye field
Oculography
Positron emission tomography

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

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10.1016/0165-1781(95)02724-B

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title = "Abnormal smooth pursuit eye movements in schizophrenic patients are associated with cerebral glucose metabolism in oculomotor regions",

abstract = "The purpose of this study was to test the hypothesis that abnormal smooth pursuit eye movements in schizophrenic patients would be related to cerebral glucose utilization in specific oculomotor regions. Eye movements were assessed with infrared oculography in 11 unmedicated schizophrenic patients and 13 normal comparison subjects. For the patients only, regional cerebral metabolic rate of glucose utilization was measured with positron emission tomography. Abnormal pursuit tracking in the patients was associated with relatively decreased metabolism in the frontal eye fields and increased metabolism in the caudate nuclei. The results are consistent with the hypothesis that these cerebral regions are involved in the pathophysiology of abnormal pursuit as related parts of a cortical-subcortical oculomotor circuit.",

keywords = "Caudate nucleus, Frontal eye field, Oculography, Positron emission tomography",

author = "Ross, {David E.} and Thaker, {Gunvant K.} and Holcomb, {Henry H.} and Cascella, {Nicola G.} and Medoff, {Deborah R.} and Tamminga, {Carol A.}",

note = "Funding Information: The authors are grateful to Jonathan Nevitt and Edward Gastineau for assistancew ith data analysis; to Philip Morris, M.D., Keith Jeffries, and Kent Hisley for assistance with imaging methodology; and to Robert Dannals, Ph.D., and his staff for assistancew ith PET scan acquisition. This study was supported in part by Clinical Research Center Grant MH-40279, a National Research Service Award (Dr. Ross), ROl MH-42234 (Dr. Tamminga), and ROl MH-43031 (Dr. Thaker) from the National Institute of Mental Health, and a Stanley Award (Dr. Ross). An earlier version of this report was presenteda t the Fourth International Congress on Schizophrenia Research in Colorado Springs, CO, April 1993.",

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doi = "10.1016/0165-1781(95)02724-B",

language = "English (US)",

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AU - Ross, David E.

AU - Thaker, Gunvant K.

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AU - Cascella, Nicola G.

AU - Medoff, Deborah R.

AU - Tamminga, Carol A.

N1 - Funding Information: The authors are grateful to Jonathan Nevitt and Edward Gastineau for assistancew ith data analysis; to Philip Morris, M.D., Keith Jeffries, and Kent Hisley for assistance with imaging methodology; and to Robert Dannals, Ph.D., and his staff for assistancew ith PET scan acquisition. This study was supported in part by Clinical Research Center Grant MH-40279, a National Research Service Award (Dr. Ross), ROl MH-42234 (Dr. Tamminga), and ROl MH-43031 (Dr. Thaker) from the National Institute of Mental Health, and a Stanley Award (Dr. Ross). An earlier version of this report was presenteda t the Fourth International Congress on Schizophrenia Research in Colorado Springs, CO, April 1993.

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N2 - The purpose of this study was to test the hypothesis that abnormal smooth pursuit eye movements in schizophrenic patients would be related to cerebral glucose utilization in specific oculomotor regions. Eye movements were assessed with infrared oculography in 11 unmedicated schizophrenic patients and 13 normal comparison subjects. For the patients only, regional cerebral metabolic rate of glucose utilization was measured with positron emission tomography. Abnormal pursuit tracking in the patients was associated with relatively decreased metabolism in the frontal eye fields and increased metabolism in the caudate nuclei. The results are consistent with the hypothesis that these cerebral regions are involved in the pathophysiology of abnormal pursuit as related parts of a cortical-subcortical oculomotor circuit.

AB - The purpose of this study was to test the hypothesis that abnormal smooth pursuit eye movements in schizophrenic patients would be related to cerebral glucose utilization in specific oculomotor regions. Eye movements were assessed with infrared oculography in 11 unmedicated schizophrenic patients and 13 normal comparison subjects. For the patients only, regional cerebral metabolic rate of glucose utilization was measured with positron emission tomography. Abnormal pursuit tracking in the patients was associated with relatively decreased metabolism in the frontal eye fields and increased metabolism in the caudate nuclei. The results are consistent with the hypothesis that these cerebral regions are involved in the pathophysiology of abnormal pursuit as related parts of a cortical-subcortical oculomotor circuit.

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KW - Oculography

KW - Positron emission tomography

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Abnormal smooth pursuit eye movements in schizophrenic patients are associated with cerebral glucose metabolism in oculomotor regions

Abstract

Keywords

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