Abnormal serum phenylalanine-tyrosine ratio and hyperferritinemia in malignant histiocytosis

Shinsaku Imashuku, Yoshihito Morioka, Naoki Kodo, Noriko Esumi, Shigeyoshi Hibi, Shinjiro Todo

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Nine cases of childhood malignant histiocytosis (MH) showed an abnormally high serum phenylalanine (Phe)/tyrosine (Tyr) ratio (3.47±1.32) coincident with hyperferritinemia (50,800 ± 33,600 ng/ml). Lactate dehydrogenase activity was also increased in these patients. These values were compared with data on sera from two groups of patients, acute leukemia cases (n==14) and measles cases (n==13), and with control values from normal healthy children (n==38). The Phe/Tyr ratio was 1.57±0.54 for the acute leukemia (p > 0.01) and 2.58 ±1.46 for the measles cases (NS), serum ferritin was 245 ± 124 ng/ml for acute leukemia (p > 0.01) and 167 ±117 ng/ml for measles (p > 0.01). Accordingly, the concurrence of both abnormalities is considered to be characteristic for MH. It was also found that both serum Phe/Tyr ratio and ferritin levels reflect the disease activity, indicating that these two factors are useful prognostic indicators in the treatment of patients with MH.

Original languageEnglish (US)
Pages (from-to)299-307
Number of pages9
JournalPediatric Hematology and Oncology
Issue number4
StatePublished - Jan 1 1988
Externally publishedYes


  • Hyperferritinemia
  • Malignant histiocytosis
  • Phenylalanine
  • Tyrosine

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology


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